PPARδ Activation Rescues Pancreatic β-Cell Line INS-1E from Palmitate-Induced Endoplasmic Reticulum Stress through Enhanced Fatty Acid Oxidation
Joint Authors
Tong, Yuzhen
Cao, Mingming
Wan, Jun
Zhang, Yuwei
Lv, Qingguo
Jiang, Li
Chen, Xiang
Long, Yang
Tong, Nanwei
Zhang, Fang
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-21
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
One of the key factors responsible for the development of type 2 diabetes is the loss of functional pancreatic β cells.
This occurs due to a chronic exposure to a high fatty acid environment.
ER stress is caused by an accumulation of irreversible misfold or unfold protein: these trigger the death of functional pancreatic β cells.
PPARδ is an orphan nuclear receptor.
It plays a pivotal role in regulating the metabolism of dietary lipids and fats.
However, the correlation between PPARδ of fatty acids and ER stress of pancreatic β cells is not quite clear till date.
Here, we show that PPARδ attenuates palmitate-induced ER stress of pancreatic β cells.
On the other hand, PPARδ agonist inhibits both abnormal changes in ER structure and activation of signaling cascade, which is downstream ER stress.
Further, we illustrate that PPARδ attenuates palmitate-induced ER stress by promoting fatty acid oxidation through treatment with etomoxir, an inhibitor of fatty acid oxidation.
It dramatically abolishes PPARδ-mediated inhibition of ER stress.
Finally, we show that PPARδ could protect pancreatic β cells from palmitate-induced cell death and dysfunction of insulin secretion.
Our work elucidates the protective effect of PPARδ on the fatty-acid-induced toxicity of pancreatic β cells.
American Psychological Association (APA)
Cao, Mingming& Tong, Yuzhen& Lv, Qingguo& Chen, Xiang& Long, Yang& Jiang, Li…[et al.]. 2012. PPARδ Activation Rescues Pancreatic β-Cell Line INS-1E from Palmitate-Induced Endoplasmic Reticulum Stress through Enhanced Fatty Acid Oxidation. PPAR Research،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-489998
Modern Language Association (MLA)
Cao, Mingming…[et al.]. PPARδ Activation Rescues Pancreatic β-Cell Line INS-1E from Palmitate-Induced Endoplasmic Reticulum Stress through Enhanced Fatty Acid Oxidation. PPAR Research No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-489998
American Medical Association (AMA)
Cao, Mingming& Tong, Yuzhen& Lv, Qingguo& Chen, Xiang& Long, Yang& Jiang, Li…[et al.]. PPARδ Activation Rescues Pancreatic β-Cell Line INS-1E from Palmitate-Induced Endoplasmic Reticulum Stress through Enhanced Fatty Acid Oxidation. PPAR Research. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-489998
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-489998