Fine-Needle Aspiration Cytology of Parathyroid Carcinoma Mimic Hürthle Cell Thyroid Neoplasm

Joint Authors

Chanplakorn, Niramol
Sriphrapradang, Chutintorn
Trachoo, Objoon
Sae-Chew, Pattarana
Sornmayura, Pattana
Aroonroch, Rangsima

Source

Case Reports in Endocrinology

Issue

Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2014-08-10

Country of Publication

Egypt

No. of Pages

7

Main Subjects

Diseases

Abstract EN

Background.

Fine-needle aspiration (FNA) can cause misdiagnosis of cytomorphological findings between parathyroid and thyroid lesions.

Case Presentation.

A 31-year-old man presented with a palpable neck mass on the right thyroid lobe.

FNA cytology was reported as intrathyroidal lymphoid hyperplasia.

After 5 years, repeated FNA was done on the enlarged nodule with result of Hürthle cell lesion.

Prior to right lobectomy, laboratories revealed elevated serum calcium and parathyroid hormone (PTH).

Careful history taking revealed chronic knee pain and ossifying fibroma at the maxilla.

Ultrasonography showed a 2.8 cm mass inferior to right thyroid lobe.

Pathology from en bloc resection was parathyroid carcinoma and immunohistochemical study revealed positivity for PTH.

Genetic analysis found somatic mutation of CDC73 gene in exon1 (c.70delG) which caused premature stop codon in amino acid 26 (p.Glu24Lysfs2*).

The final diagnosis was hyperparathyroidism-jaw tumor syndrome.

Conclusions.

FNA cytology of parathyroid can mimic thyroid lesion.

It is important to consider and correlate the entire information from clinical history, laboratory, imaging, and FNA.

American Psychological Association (APA)

Sriphrapradang, Chutintorn& Sornmayura, Pattana& Chanplakorn, Niramol& Trachoo, Objoon& Sae-Chew, Pattarana& Aroonroch, Rangsima. 2014. Fine-Needle Aspiration Cytology of Parathyroid Carcinoma Mimic Hürthle Cell Thyroid Neoplasm. Case Reports in Endocrinology،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-490018

Modern Language Association (MLA)

Sriphrapradang, Chutintorn…[et al.]. Fine-Needle Aspiration Cytology of Parathyroid Carcinoma Mimic Hürthle Cell Thyroid Neoplasm. Case Reports in Endocrinology No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-490018

American Medical Association (AMA)

Sriphrapradang, Chutintorn& Sornmayura, Pattana& Chanplakorn, Niramol& Trachoo, Objoon& Sae-Chew, Pattarana& Aroonroch, Rangsima. Fine-Needle Aspiration Cytology of Parathyroid Carcinoma Mimic Hürthle Cell Thyroid Neoplasm. Case Reports in Endocrinology. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-490018

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-490018