![](/images/graphics-bg.png)
Topical Application of Cleome viscosa Increases the Expression of Basic Fibroblast Growth Factor and Type III Collagen in Rat Cutaneous Wound
Joint Authors
Upadhyay, Aadesh
Goyary, Danswrang
Chattopadhyay, Pronobesh
Veer, Vijay
Mazumder, Papiya M.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-17
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Cleome viscosa L.
(Cleomaceae) is an important traditional medicine of the Indian-Ayurvedic and Chinese-medicine system documented for rheumatic arthritis, hypertension, malaria, neurasthenia, and wound healing.
The plant is also known as Asian spider flower and is distributed throughout the greater part of India.
The present study explored the wound healing property of C.
viscosa methanol extract (CvME) and its related mechanism using Wistar rat cutaneous excision wound model.
Wound contraction rate, hydroxyproline quantification, and histopathological examination of wound granulation tissue were performed.
The healing potential was comparatively assessed with a reference gentamicin sulfate hydrogel (0.01% w/w).
Western blot for COL3A1, bFGF, and Smad-2, Smad-3, Smad-4, and Smad-7 was performed with 7-day postoperative granulation tissue.
Results revealed that the topical application of CvME (2.5% w/w) significantly accelerated the wound contraction rate (95.14%, 24 postoperative days), increased the hydroxyproline content (3.947 mg/100 mg tissue), and improved histopathology of wound tissue as compared to control groups.
Western blot analysis revealed that CvME significantly upregulated the expression of COL3A1 and bFGF and increased the Smad-mediated collagen production in granulation tissue.
These findings suggest that C.
viscosa promoted the wound repair process by attenuating the Smad-mediated collagen production in wound granulation tissue.
American Psychological Association (APA)
Upadhyay, Aadesh& Chattopadhyay, Pronobesh& Goyary, Danswrang& Mazumder, Papiya M.& Veer, Vijay. 2014. Topical Application of Cleome viscosa Increases the Expression of Basic Fibroblast Growth Factor and Type III Collagen in Rat Cutaneous Wound. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-490019
Modern Language Association (MLA)
Upadhyay, Aadesh…[et al.]. Topical Application of Cleome viscosa Increases the Expression of Basic Fibroblast Growth Factor and Type III Collagen in Rat Cutaneous Wound. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-490019
American Medical Association (AMA)
Upadhyay, Aadesh& Chattopadhyay, Pronobesh& Goyary, Danswrang& Mazumder, Papiya M.& Veer, Vijay. Topical Application of Cleome viscosa Increases the Expression of Basic Fibroblast Growth Factor and Type III Collagen in Rat Cutaneous Wound. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-490019
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-490019