Expression of Phosphatase Regenerating Liver-1 in Esophageal Squamous Cell Carcinoma Associated with Metastasis
Joint Authors
Li, Huixiang
Guo, Ke
Lei, Jun-Yi
Lou, Xi
Liu, Yuqiong
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-08
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Expression of PRL-1 protein was examined with immunohistochemistry in 60 cases of esophageal squamous cell carcinoma (ESCC) with matched lymph node metastasis (n=40) and 6 cases of esophageal adenocarcinoma.
Its association with ESCC metastasis was also explored.
The results showed that PRL-1 protein was more frequently expressed in ESCC with metastasis (31/40, 77.5%) than in ESCC without metastasis (10/20, 50%, P=.031) and more in metastatic ESCC (39/40, 97.5%) than primary ESCC (68.3%, P=.003).
PRL-1 protein expression significantly correlated with the stage of ESCC, 79.4% (27/34) in stage III ESCC and 33.3% (1/3) in stage 1 ESCC (P=.003).
PRL-1 protein was characteristically expressed in the nuclei, in addition to the cytoplasm, of 3 out of 4 (66.7%) poorly differentiated esophageal adenocarcinoma.
These findings suggest that PRL-1 may serve as the potential biomarker to predict the metastasis of ESCC and a better biomarker than PRL-3 in the differential diagnosis of poorly differentiated ESCC.
American Psychological Association (APA)
Liu, Yuqiong& Lou, Xi& Guo, Ke& Lei, Jun-Yi& Li, Huixiang. 2011. Expression of Phosphatase Regenerating Liver-1 in Esophageal Squamous Cell Carcinoma Associated with Metastasis. ISRN Pathology،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-490020
Modern Language Association (MLA)
Liu, Yuqiong…[et al.]. Expression of Phosphatase Regenerating Liver-1 in Esophageal Squamous Cell Carcinoma Associated with Metastasis. ISRN Pathology No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-490020
American Medical Association (AMA)
Liu, Yuqiong& Lou, Xi& Guo, Ke& Lei, Jun-Yi& Li, Huixiang. Expression of Phosphatase Regenerating Liver-1 in Esophageal Squamous Cell Carcinoma Associated with Metastasis. ISRN Pathology. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-490020
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-490020