Expression of Endothelial Nitric Oxide Synthase and Endothelin-1 in Skin Tissue from Amputated Limbs of Patients with Complex Regional Pain Syndrome
Joint Authors
Zijlstra, Freek J.
Heijmans-Antonissen, Claudia
Huygen, Frank J. P. M.
Groeneweg, J. George
Source
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2008-07-20
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Background and Objectives.
Impaired microcirculation during the chronic stage of complex regional pain syndrome (CRPS) is related to increased vasoconstriction, tissue hypoxia, and metabolic tissue acidosis in the affected limb.
Endothelial dysfunction is suggested to be the main cause of diminished blood flow.
The aim of this study was to examine the distribution of endothelial nitric oxide synthase (eNOS) and endothelin-1(ET-1) relative to vascular density represented by the endothelial marker CD31-immunoreactivity in the skin tissue of patients with chronic CRPS.
Methods.
We performed immunohistochemical staining on sections of skin specimens obtained from the amputated limbs (one arm and one leg) of two patients with CRPS.
Results.
In comparison to proximal specimens we found an increased number of migrated endothelial cells as well as an increase of eNOS activity in distal dermis specimens.
Conclusions.
We found indications that endothelial dysfunction plays a role in chronic CRPS.
American Psychological Association (APA)
Groeneweg, J. George& Heijmans-Antonissen, Claudia& Huygen, Frank J. P. M.& Zijlstra, Freek J.. 2008. Expression of Endothelial Nitric Oxide Synthase and Endothelin-1 in Skin Tissue from Amputated Limbs of Patients with Complex Regional Pain Syndrome. Mediators of Inflammation،Vol. 2008, no. 2008, pp.1-5.
https://search.emarefa.net/detail/BIM-490031
Modern Language Association (MLA)
Groeneweg, J. George…[et al.]. Expression of Endothelial Nitric Oxide Synthase and Endothelin-1 in Skin Tissue from Amputated Limbs of Patients with Complex Regional Pain Syndrome. Mediators of Inflammation No. 2008 (2008), pp.1-5.
https://search.emarefa.net/detail/BIM-490031
American Medical Association (AMA)
Groeneweg, J. George& Heijmans-Antonissen, Claudia& Huygen, Frank J. P. M.& Zijlstra, Freek J.. Expression of Endothelial Nitric Oxide Synthase and Endothelin-1 in Skin Tissue from Amputated Limbs of Patients with Complex Regional Pain Syndrome. Mediators of Inflammation. 2008. Vol. 2008, no. 2008, pp.1-5.
https://search.emarefa.net/detail/BIM-490031
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-490031