The Redox Imbalance and the Reduction of Contractile Protein Content in Rat Hearts Administered with L-Thyroxine and Doxorubicin
Joint Authors
Burdan, Franciszek
Sliwinska, Justyna
Dawidek-Pietryka, Katarzyna
Dudka, Jaroslaw
Korga, Agnieszka
Mandziuk, Slawomir
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-26
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Oxidative stress and disorders in calcium balance play a crucial role in the doxorubicin-induced cardiotoxicity.
Moreover, many cardiotoxic targets of doxorubicin are regulated by iodothyronine hormones.
The aim of the study was to evaluate effects of tetraiodothyronine (0.2, 2 mg/L) on oxidative stress in the cardiac muscle as well as contractility and cardiomyocyte damage markers in rats receiving doxorubicin (1.5 mg/kg) once a week for ten weeks.
Doxorubicin was administered alone (DOX) or together with a lower (0.2T4 + DOX) and higher dose of tetraiodothyronine (2T4 + DOX).
Two groups received only tetraiodothyronine (0.2T4, 2T4).
Coadministration of tetraiodothyronine and doxorubicin increased the level of lipid peroxidation products and reduced RyR2 level when compared to untreated control and group exposed exclusively to doxorubicin.
Insignificant differences in SERCA2 and occasional histological changes were observed.
In conclusion, an increase of tetraiodothyronine level may be an additional risk factor of redox imbalance and RyR2 reduction in anthracycline cardiotoxicity.
American Psychological Association (APA)
Korga, Agnieszka& Dudka, Jaroslaw& Burdan, Franciszek& Sliwinska, Justyna& Mandziuk, Slawomir& Dawidek-Pietryka, Katarzyna. 2012. The Redox Imbalance and the Reduction of Contractile Protein Content in Rat Hearts Administered with L-Thyroxine and Doxorubicin. Oxidative Medicine and Cellular Longevity،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-490056
Modern Language Association (MLA)
Korga, Agnieszka…[et al.]. The Redox Imbalance and the Reduction of Contractile Protein Content in Rat Hearts Administered with L-Thyroxine and Doxorubicin. Oxidative Medicine and Cellular Longevity No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-490056
American Medical Association (AMA)
Korga, Agnieszka& Dudka, Jaroslaw& Burdan, Franciszek& Sliwinska, Justyna& Mandziuk, Slawomir& Dawidek-Pietryka, Katarzyna. The Redox Imbalance and the Reduction of Contractile Protein Content in Rat Hearts Administered with L-Thyroxine and Doxorubicin. Oxidative Medicine and Cellular Longevity. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-490056
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-490056