Improvement of the Bioavailability and Glycaemic Metabolism of Cinnamon Oil in Rats by Liquid Loadable Tablets
Joint Authors
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-01
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Medicine
Information Technology and Computer Science
Abstract EN
The purpose of this study is to investigate the bioavailability and glycaemic metabolism of cinnamon oil (CIO) carried by liquid-loadable tablets (CIO-LLTs), the carrier of a CIO self-emulsifying formulation (CIO-LS).
The results of tests performed to evaluate the physical properties of the CIO-LLT complied with Chinese Pharmacopeia (2010).
The release profile suggested that the CIO-LLT preserved the enhancement of in vitro dissolution of cio.
After orally administration, the plasma concentration-time profile and pharmacokinetic parameters suggested that a significant increase (P<0.0001) in the Cmax, AUC and F were observed in the CIO-LLT.
The blood glucose and the HbA1c were significantly decreased in alloxan-induced hyperglycemic rats (P<0.05, P<0.01, resp.), while the level of insulin secretion was markedly elevated in alloxan-induced hyperglycemic rats (P<0.05).
The alloxan-damaged pancreatic β-cells of the rats were partly recovered gradually after the rats were administered with CIO-LLT 45 days later.
CIO-LLT could improve the bioavailability and glycaemic metabolism of CIO.
American Psychological Association (APA)
Han, Chunchao& Cui, Bo. 2012. Improvement of the Bioavailability and Glycaemic Metabolism of Cinnamon Oil in Rats by Liquid Loadable Tablets. The Scientific World Journal،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-490076
Modern Language Association (MLA)
Han, Chunchao& Cui, Bo. Improvement of the Bioavailability and Glycaemic Metabolism of Cinnamon Oil in Rats by Liquid Loadable Tablets. The Scientific World Journal No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-490076
American Medical Association (AMA)
Han, Chunchao& Cui, Bo. Improvement of the Bioavailability and Glycaemic Metabolism of Cinnamon Oil in Rats by Liquid Loadable Tablets. The Scientific World Journal. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-490076
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-490076