SEA Antagonizes the Imatinib-Meditated Inhibitory Effects on T Cell Activation via the TCR Signaling Pathway
Joint Authors
Lin, Chen
Yan, Yuhui
Wang, Guanming
Li, Yangqiu
Chen, Xiaohua
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-02
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The BCR-ABL kinase inhibitor imatinib is highly effective in the treatment of chronic myeloid leukemia (CML).
However, long-term imatinib treatment induces immunosuppression, which is mainly due to T cell dysfunction.
Imatinib can reduce TCR-triggered T cell activation by inhibiting the phosphorylation of tyrosine kinases such as Lck, ZAP70, LAT, and PLCγ1 early in the TCR signaling pathway.
The purpose of this study was to investigate whether the superantigen SEA, a potent T cell stimulator, can block the immunosuppressive effects of imatinib on T cells.
Our data show that the exposure of primary human T cells and Jurkat cells to SEA for 24 h leads to the upregulation of the Lck and ZAP70 proteins in a dose-dependent manner.
T cells treated with SEA prior to TCR binding had increased the tyrosine phosphorylation of Lck, ZAP70, and PLCγ1.
Pretreatment with SEA prevents the inhibitory effects of imatinib on TCR signaling, which leads to T cell proliferation and IL-2 production.
It is conceivable that SEA antagonizes the imatinib-mediated inhibition of T cell activation and proliferation through the TCR signaling pathway.
American Psychological Association (APA)
Wang, Guanming& Yan, Yuhui& Chen, Xiaohua& Lin, Chen& Li, Yangqiu. 2014. SEA Antagonizes the Imatinib-Meditated Inhibitory Effects on T Cell Activation via the TCR Signaling Pathway. BioMed Research International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-490122
Modern Language Association (MLA)
Wang, Guanming…[et al.]. SEA Antagonizes the Imatinib-Meditated Inhibitory Effects on T Cell Activation via the TCR Signaling Pathway. BioMed Research International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-490122
American Medical Association (AMA)
Wang, Guanming& Yan, Yuhui& Chen, Xiaohua& Lin, Chen& Li, Yangqiu. SEA Antagonizes the Imatinib-Meditated Inhibitory Effects on T Cell Activation via the TCR Signaling Pathway. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-490122
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-490122