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Microbleeds in Late-Life Depression : Comparison of Early- and Late-Onset Depression
Joint Authors
Feng, Chao
Xu, Yu
Fang, Min
Hua, Ting
Liu, Xue-Yuan
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-26
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Late-life depression could be classified roughly as early-onset depression (EOD) and late-onset depression (LOD).
LOD was proved to be associated with cerebral lesions including white matter hyperintensities (WMH) and silent brain infarctions (SBI), differently from EOD.
However, it is unclear whether similar association is present between LOD and microbleeds which are also silent lesions.
In this study, 195 patients of late-life depression were evaluated and divided into EOD, presenile-onset depression (POD), and LOD groups; 85 healthy elderly controls were enrolled as controls.
Subjects were scanned by MRI including susceptibility weighted images to evaluate white matter hyperintensities (WMH), silent brain infarctions (SBI), and microbleeds.
The severity of depression was evaluated with 15-item Geriatric Depression Scale.
Psychosocial factors were investigated with Scale of Life Events and Lubben Social Network Scale.
Logistic regression and linear regression were performed to identify the independent risk factors for depression.
Results showed that LOD patients had higher prevalence of microbleeds than EOD, POD, and control patients.
The prevalence of lobar microbleeds and microbleeds in the left hemisphere was the independent risk factor for the occurrence of LOD; a high number of microbleeds were associated with severe state of LOD, whereas life events and lack of social support were more important for EOD and POD.
All these results indicated that Microbleeds especially lobar microbleeds and microbleeds in the left hemisphere were associated with LOD but not with EOD.
American Psychological Association (APA)
Feng, Chao& Fang, Min& Xu, Yu& Hua, Ting& Liu, Xue-Yuan. 2014. Microbleeds in Late-Life Depression : Comparison of Early- and Late-Onset Depression. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-490131
Modern Language Association (MLA)
Xu, Yu…[et al.]. Microbleeds in Late-Life Depression : Comparison of Early- and Late-Onset Depression. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-490131
American Medical Association (AMA)
Feng, Chao& Fang, Min& Xu, Yu& Hua, Ting& Liu, Xue-Yuan. Microbleeds in Late-Life Depression : Comparison of Early- and Late-Onset Depression. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-490131
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-490131