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CD200 : CD200R-Mediated Regulation of Immunity
Author
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-18, 18 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-12
Country of Publication
Egypt
No. of Pages
18
Main Subjects
Abstract EN
The type 1 membrane glycoprotein CD200, widely expressed on multiple cells/tissues, uses a structurally similar receptor (CD200R1), whose expression is more restricted to cells of the myeloid and lymphoid lineages, to transmit signals affecting responses in multiple physiological systems.
Thus CD200 expression is reported to exert effects on cancer growth, autoimmune and allergic disorders, infection, transplantation, bone development and homeostasis, and reproductive biology.
It was initially thought, based on the idea that CD200R1 was mostly expressed on cells of myeloid origin, that CD200:CD200R1 interactions were primarily dedicated to controlling myeloid cell function.
However additional members of the CD200R family have now also been identified, although their function(s) remain unclear, and CD200R1 itself is now known to be expressed by subsets of T cells and other cells.
Together these observations add layers of complexity to our understanding of CD200-related regulation.
In common with a number of physiological systems, the mechanism(s) of CD200-induced signaling seem to fit within a similar framework of opposing actions of kinases and phosphatases.
This paper highlights the advances in our knowledge of immunoregulation achieved following CD200:CD200R interaction and the potential clinical applicability of that information.
American Psychological Association (APA)
Gorczynski, Reginald M.. 2012. CD200 : CD200R-Mediated Regulation of Immunity. ISRN Immunology،Vol. 2012, no. 2012, pp.1-18.
https://search.emarefa.net/detail/BIM-490144
Modern Language Association (MLA)
Gorczynski, Reginald M.. CD200 : CD200R-Mediated Regulation of Immunity. ISRN Immunology No. 2012 (2012), pp.1-18.
https://search.emarefa.net/detail/BIM-490144
American Medical Association (AMA)
Gorczynski, Reginald M.. CD200 : CD200R-Mediated Regulation of Immunity. ISRN Immunology. 2012. Vol. 2012, no. 2012, pp.1-18.
https://search.emarefa.net/detail/BIM-490144
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-490144