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Hepatitis B Virus-Encoded X Protein Downregulates EGFR Expression via Inducing MicroRNA-7 in Hepatocellular Carcinoma Cells
Joint Authors
Chen, Jhen-Yu
Lin, Chih-Wen
Yu, Yung-Luen
Huang, Wei-Chien
Chen, Yun-Ju
Chien, Pei-Hsuan
Chen, Wen-Shu
Huang, Tzung-Chi
Chien, Yu-Fong
Hsu, Min-Hsiang
Wang, Li-Yun
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-11
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Hepatitis B virus (HBV) infection accounts for over a half of cases of hepatocellular carcinoma (HCC), the most frequent malignant tumor of the liver.
HBV-encoded X (HBx) plays critical roles in HBV-associated hepatocarcinogenesis.
However, it is unclear whether and how HBx regulates the expression of epidermal growth factor receptor (EGFR), an important gene for cell growth.
Therefore, the study aimed to investigate the association between HBx and EGFR expression.
In this study, we found that HBx upregulates miR-7 expression to target 3′UTR of EGFR mRNA, which in turn results in the reduction of EGFR protein expression in HCC cells.
HBx-mediated EGFR suppression renders HCC cells a slow-growth behavior.
Deprivation of HBx or miR-7 expression or restoration of EGFR expression can increase the growth rate of HCC cells.
Our data showed the miR-7-dependent EGFR suppression by HBx, supporting an inhibitory role of HBx in the cell growth of HCC.
These findings not only identify miR-7 as a novel regulatory target of HBx, but also suggest HBx-miR-7-EGFR as a critical signaling in controlling the growth rate of HCC cells.
American Psychological Association (APA)
Chen, Yun-Ju& Chien, Pei-Hsuan& Chen, Wen-Shu& Chien, Yu-Fong& Hsu, Min-Hsiang& Wang, Li-Yun…[et al.]. 2013. Hepatitis B Virus-Encoded X Protein Downregulates EGFR Expression via Inducing MicroRNA-7 in Hepatocellular Carcinoma Cells. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-490155
Modern Language Association (MLA)
Chen, Yun-Ju…[et al.]. Hepatitis B Virus-Encoded X Protein Downregulates EGFR Expression via Inducing MicroRNA-7 in Hepatocellular Carcinoma Cells. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-490155
American Medical Association (AMA)
Chen, Yun-Ju& Chien, Pei-Hsuan& Chen, Wen-Shu& Chien, Yu-Fong& Hsu, Min-Hsiang& Wang, Li-Yun…[et al.]. Hepatitis B Virus-Encoded X Protein Downregulates EGFR Expression via Inducing MicroRNA-7 in Hepatocellular Carcinoma Cells. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-490155
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-490155