Fructose : A Key Factor in the Development of Metabolic Syndrome and Hypertension
Joint Authors
Source
Journal of Nutrition and Metabolism
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-05-25
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Diabetes mellitus and the metabolic syndrome are becoming leading causes of death in the world.
Identifying the etiology of diabetes is key to prevention.
Despite the similarity in their structures, fructose and glucose are metabolized in different ways.
Uric acid, a byproduct of uncontrolled fructose metabolism is known risk factor for hypertension.
In the liver, fructose bypasses the two highly regulated steps in glycolysis, glucokinase and phosphofructokinase, both of which are inhibited by increasing concentrations of their byproducts.
Fructose is metabolized by fructokinase (KHK).
KHK has no negative feedback system, and ATP is used for phosphorylation.
This results in intracellular phosphate depletion and the rapid generation of uric acid due to activation of AMP deaminase.
Uric acid, a byproduct of this reaction, has been linked to endothelial dysfunction, insulin resistance, and hypertension.
We present possible mechanisms by which fructose causes insulin resistance and suggest actions based on this association that have therapeutic implications.
American Psychological Association (APA)
Khitan, Zeid& Kim, Dong Hyun. 2013. Fructose : A Key Factor in the Development of Metabolic Syndrome and Hypertension. Journal of Nutrition and Metabolism،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-490183
Modern Language Association (MLA)
Khitan, Zeid& Kim, Dong Hyun. Fructose : A Key Factor in the Development of Metabolic Syndrome and Hypertension. Journal of Nutrition and Metabolism No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-490183
American Medical Association (AMA)
Khitan, Zeid& Kim, Dong Hyun. Fructose : A Key Factor in the Development of Metabolic Syndrome and Hypertension. Journal of Nutrition and Metabolism. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-490183
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-490183