Retroviral Env Glycoprotein Trafficking and Incorporation into Virions
Author
Source
Molecular Biology International
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-02
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Together with the Gag protein, the Env glycoprotein is a major retroviral structural protein and is essential for forming infectious virus particles.
Env is synthesized, processed, and transported to certain microdomains at the plasma membrane and takes advantage of the same host machinery for its trafficking as that used by cellular glycoproteins.
Incorporation of Env into progeny virions is probably mediated by the interaction between Env and Gag, in some cases with the additional involvement of certain host factors.
Although several general models have been proposed to explain the incorporation of retroviral Env glycoproteins into virions, the actual mechanism for this process is still unclear, partly because structural data on the Env protein cytoplasmic tail is lacking.
This paper presents the current understanding of the synthesis, trafficking, and virion incorporation of retroviral Env proteins.
American Psychological Association (APA)
Murakami, Tsutomu. 2012. Retroviral Env Glycoprotein Trafficking and Incorporation into Virions. Molecular Biology International،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-490199
Modern Language Association (MLA)
Murakami, Tsutomu. Retroviral Env Glycoprotein Trafficking and Incorporation into Virions. Molecular Biology International No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-490199
American Medical Association (AMA)
Murakami, Tsutomu. Retroviral Env Glycoprotein Trafficking and Incorporation into Virions. Molecular Biology International. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-490199
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-490199