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Involvement of Nitric Oxide in a Rat Model of Carrageenin-Induced Pleurisy
Joint Authors
Iwata, Masahiro
Suzuki, Shigeyuki
Inoue, Takayuki
Asai, Yuji
Takagi, Kenji
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-06-02
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Some evidence indicates that nitric oxide (NO) contributes to inflammation, while other evidence supports the opposite conclusion.
To clarify the role of NO in inflammation, we studied carrageenin-induced pleurisy in rats treated with an NO donor (NOC-18), a substrate for NO formation (L-arginine), and/or an NO synthase inhibitor (S-(2-aminoethyl) isothiourea or NG-nitro-L-arginine).
We assessed inflammatory cell migration, nitrite/nitrate values, lipid peroxidation and pro-inflammatory mediators.
NOC-18 and L-arginine reduced the migration of inflammatory cells and edema, lowered oxidative stress, and normalized antioxidant enzyme activities.
NO synthase inhibitors increased the exudate formation and inflammatory cell number, contributed to oxidative stress, induced an oxidant/antioxidant imbalance by maintaining high O2−, and enhanced the production of pro-inflammatory mediators.
L-arginine and NOC-18 reversed the proinflammatory effects of NO synthase inhibitors, perhaps by reducing the expression of adhesion molecules on endothelial cells.
Thus, our results indicate that NO is involved in blunting—not enhancing—the inflammatory response.
American Psychological Association (APA)
Iwata, Masahiro& Suzuki, Shigeyuki& Asai, Yuji& Inoue, Takayuki& Takagi, Kenji. 2010. Involvement of Nitric Oxide in a Rat Model of Carrageenin-Induced Pleurisy. Mediators of Inflammation،Vol. 2010, no. 2010, pp.1-11.
https://search.emarefa.net/detail/BIM-490201
Modern Language Association (MLA)
Iwata, Masahiro…[et al.]. Involvement of Nitric Oxide in a Rat Model of Carrageenin-Induced Pleurisy. Mediators of Inflammation No. 2010 (2010), pp.1-11.
https://search.emarefa.net/detail/BIM-490201
American Medical Association (AMA)
Iwata, Masahiro& Suzuki, Shigeyuki& Asai, Yuji& Inoue, Takayuki& Takagi, Kenji. Involvement of Nitric Oxide in a Rat Model of Carrageenin-Induced Pleurisy. Mediators of Inflammation. 2010. Vol. 2010, no. 2010, pp.1-11.
https://search.emarefa.net/detail/BIM-490201
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-490201