Transport Reversal during Heteroexchange : A Kinetic Study
Joint Authors
Kucheryavykh, Y. V.
Eaton, M. J.
Makarov, V.
Rivera, A.
Inyushin, M.
Skatchkov, S. N.
Kucheryavykh, L. Y.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-26
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
It is known that secondary transporters, which utilize transmembrane ionic gradients to drive their substrates up a concentration gradient, can reverse the uptake and instead release their substrates.
Unfortunately, the Michaelis-Menten kinetic scheme, which is popular in transporter studies, does not include transporter reversal, and it completely neglects the possibility of equilibrium between the substrate concentrations on both sides of the membrane.
We have developed a complex two-substrate kinetic model that includes transport reversal.
This model allows us to construct analytical formulas allowing the calculation of a “heteroexchange” and “transacceleration” using standard Michaelis coefficients for respective substrates.
This approach can help to understand how glial and other cells accumulate substrates without synthesis and are able to release such substrates and gliotransmitters.
American Psychological Association (APA)
Makarov, V.& Kucheryavykh, L. Y.& Kucheryavykh, Y. V.& Rivera, A.& Eaton, M. J.& Skatchkov, S. N.…[et al.]. 2013. Transport Reversal during Heteroexchange : A Kinetic Study. Journal of Biophysics،Vol. 2013, no. 2013, pp.1-14.
https://search.emarefa.net/detail/BIM-490243
Modern Language Association (MLA)
Makarov, V.…[et al.]. Transport Reversal during Heteroexchange : A Kinetic Study. Journal of Biophysics No. 2013 (2013), pp.1-14.
https://search.emarefa.net/detail/BIM-490243
American Medical Association (AMA)
Makarov, V.& Kucheryavykh, L. Y.& Kucheryavykh, Y. V.& Rivera, A.& Eaton, M. J.& Skatchkov, S. N.…[et al.]. Transport Reversal during Heteroexchange : A Kinetic Study. Journal of Biophysics. 2013. Vol. 2013, no. 2013, pp.1-14.
https://search.emarefa.net/detail/BIM-490243
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-490243