Arginase in Parasitic Infections : Macrophage Activation, Immunosuppression, and Intracellular Signals
Joint Authors
Cerban, Fabio M.
Dulgerian, Laura R.
Stempin, Cinthia C.
Garrido, Vanina V.
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-12-09
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
A type 1 cytokine-dependent proinflammatory response inducing classically activated macrophages (CaMϕs) is crucial for parasite control during protozoan infections but can also contribute to the development of immunopathological disease symptoms.
Type 2 cytokines such as IL-4 and IL-13 antagonize CaMϕs inducing alternatively activated macrophages (AaMϕs) that upregulate arginase-1 expression.
During several infections, induction of arginase-1-macrophages was showed to have a detrimental role by limiting CaMϕ-dependent parasite clearance and promoting parasite proliferation.
Additionally, the role of arginase-1 in T cell suppression has been explored recently.
Arginase-1 can also be induced by IL-10 and transforming growth factor-β (TGF-β) or even directly by parasites or parasite components.
Therefore, generation of alternative activation states of macrophages could limit collateral tissue damage because of excessive type 1 inflammation.
However, they affect disease outcome by promoting parasite survival and proliferation.
Thus, modulation of macrophage activation may be instrumental in allowing parasite persistence and long-term host survival.
American Psychological Association (APA)
Stempin, Cinthia C.& Dulgerian, Laura R.& Garrido, Vanina V.& Cerban, Fabio M.. 2009. Arginase in Parasitic Infections : Macrophage Activation, Immunosuppression, and Intracellular Signals. Journal of Biomedicine and Biotechnology،Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-490256
Modern Language Association (MLA)
Stempin, Cinthia C.…[et al.]. Arginase in Parasitic Infections : Macrophage Activation, Immunosuppression, and Intracellular Signals. Journal of Biomedicine and Biotechnology No. 2010 (2010), pp.1-10.
https://search.emarefa.net/detail/BIM-490256
American Medical Association (AMA)
Stempin, Cinthia C.& Dulgerian, Laura R.& Garrido, Vanina V.& Cerban, Fabio M.. Arginase in Parasitic Infections : Macrophage Activation, Immunosuppression, and Intracellular Signals. Journal of Biomedicine and Biotechnology. 2009. Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-490256
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-490256