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Oxidative Toxicity in Neurodegenerative Diseases : Role of Mitochondrial Dysfunction and Therapeutic Strategies
Joint Authors
Stohs, Sidney J.
Facecchia, Katie
Ray, Sidhartha D.
Pandey, Siyaram
Fochesato, Lee-Anne
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-07-14
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Pharmacy, Health & Medical Sciences
Medicine
Abstract EN
Besides fluorine, oxygen is the most electronegative element with the highest reduction potential in biological systems.
Metabolic pathways in mammalian cells utilize oxygen as the ultimate oxidizing agent to harvest free energy.
They are very efficient, but not without risk of generating various oxygen radicals.
These cells have good antioxidative defense mechanisms to neutralize these radicals and prevent oxidative stress.
However, increased oxidative stress results in oxidative modifications in lipid, protein, and nucleic acids, leading to mitochondrial dysfunction and cell death.
Oxidative stress and mitochondrial dysfunction have been implicated in many neurodegenerative disorders including Alzheimer's disease, Parkinson's disease, and stroke-related brain damage.
Research has indicated mitochondria play a central role in cell suicide.
An increase in oxidative stress causes mitochondrial dysfunction, leading to more production of reactive oxygen species and eventually mitochondrial membrane permeabilization.
Once the mitochondria are destabilized, cells are destined to commit suicide.
Therefore, antioxidative agents alone are not sufficient to protect neuronal loss in many neurodegenerative diseases.
Combinatorial treatment with antioxidative agents could stabilize mitochondria and may be the most suitable strategy to prevent neuronal loss.
This review discusses recent work related to oxidative toxicity in the central nervous system and strategies to treat neurodegenerative diseases.
American Psychological Association (APA)
Facecchia, Katie& Fochesato, Lee-Anne& Ray, Sidhartha D.& Stohs, Sidney J.& Pandey, Siyaram. 2011. Oxidative Toxicity in Neurodegenerative Diseases : Role of Mitochondrial Dysfunction and Therapeutic Strategies. Journal of Toxicology،Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-490279
Modern Language Association (MLA)
Facecchia, Katie…[et al.]. Oxidative Toxicity in Neurodegenerative Diseases : Role of Mitochondrial Dysfunction and Therapeutic Strategies. Journal of Toxicology No. 2011 (2011), pp.1-12.
https://search.emarefa.net/detail/BIM-490279
American Medical Association (AMA)
Facecchia, Katie& Fochesato, Lee-Anne& Ray, Sidhartha D.& Stohs, Sidney J.& Pandey, Siyaram. Oxidative Toxicity in Neurodegenerative Diseases : Role of Mitochondrial Dysfunction and Therapeutic Strategies. Journal of Toxicology. 2011. Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-490279
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-490279