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Granulomatous Lung Disease Requiring Mechanical Ventilation Induced by a Single Application of Oxaliplatin-Based Chemotherapy for Colorectal Cancer : A Case Report
Joint Authors
Amann, Kerstin U.
Neurath, Markus F.
Strauß, Richard
Siebler, Jürgen
Boxberger, Frank
Männlein, Gudrun
Albrecht, Heinz
Hohenberger, Werner
Wildner, Dane
Wein, Axel
Janka, Rolf
Wolff, Kerstin
Source
Case Reports in Oncological Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-04-08
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Combined chemotherapeutic regimens in conjunction with oxaliplatin are considered safe and effective treatment options in the clinical management of metastatic colorectal cancer.
A 62-year-old male patient with a metastatic rectal carcinoma developed a pulmonary reaction after the first application of the combined standard chemotherapy regimen (5-fluorouracil and sodium folinic acid as a 24 h infusion and oxaliplatin).
Following the first dose of chemotherapy, the patient developed acute dyspnoea and fever.
A computerised scan of the chest revealed bilateral pulmonary patchy consolidation.
Despite high-dose empiric antibiotic and antimycotic treatment, no clinical improvement was seen.
The patient's condition deteriorated, and he required invasive mechanical ventilation.
Diagnostic thoracoscopic wedge resections were performed for further diagnosis.
The histological workup revealed distinct granulomatous inflammation, but no microbial pathogens were to be found.
Thereupon, a drug-induced reaction to chemotherapy was suspected and high-dose steroid treatment initiated.
Subsequently, the patient's respiratory condition improved and he was extubated.
The present case exemplifies the rare course of a bilateral pneumonia-like, drug-induced granulomatous reaction following a single application of oxaliplatin.
In addition to the known side effects of oxaliplatin-containing combination chemotherapy, unexpected serious adverse events in the form of pulmonary toxicities should also be taken into account.
American Psychological Association (APA)
Wildner, Dane& Boxberger, Frank& Wein, Axel& Wolff, Kerstin& Albrecht, Heinz& Männlein, Gudrun…[et al.]. 2013. Granulomatous Lung Disease Requiring Mechanical Ventilation Induced by a Single Application of Oxaliplatin-Based Chemotherapy for Colorectal Cancer : A Case Report. Case Reports in Oncological Medicine،Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-490291
Modern Language Association (MLA)
Wildner, Dane…[et al.]. Granulomatous Lung Disease Requiring Mechanical Ventilation Induced by a Single Application of Oxaliplatin-Based Chemotherapy for Colorectal Cancer : A Case Report. Case Reports in Oncological Medicine No. 2013 (2013), pp.1-5.
https://search.emarefa.net/detail/BIM-490291
American Medical Association (AMA)
Wildner, Dane& Boxberger, Frank& Wein, Axel& Wolff, Kerstin& Albrecht, Heinz& Männlein, Gudrun…[et al.]. Granulomatous Lung Disease Requiring Mechanical Ventilation Induced by a Single Application of Oxaliplatin-Based Chemotherapy for Colorectal Cancer : A Case Report. Case Reports in Oncological Medicine. 2013. Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-490291
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-490291