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Expression of the Metastasis Suppressor KAI1 in Uveal Melanoma
Joint Authors
Penteado, Rafaella Cleto
Bravo-Filho, Vasco
Burnier, Miguel N.
Maloney, Shawn C.
Antecka, Emilia
Fernandes, Bruno F.
Sanft, Debra Meghan
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-08-01
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Introduction.
Uveal melanoma (UM) is an intraocular tumor that leads to metastatic disease in approximately 50% of afflicted patients.
There is no efficacious treatment for metastatic disease in this cancer.
Identification of markers that can offer prognostic and therapeutic value is a major focus in this field at present.
KAI1 is a metastasis suppressor gene that has been reported to play a role in various human malignancies, although it has not previously been evaluated in UM.
Purpose.
To investigate the expression of KAI1 in UM and its potential value as a prognostic marker.
Materials and Methods.
18 cases of human primary UM were collected and immunostained for KAI1 expression.
A pathologist evaluated staining intensity and distribution semiquantitatively.
Each case was categorized as group 1 (low staining) or group 2 (high staining).
Results.
In group 2, two of the 12 cases presented with metastasis.
Conversely, in group 1, five out of 6 cases had metastasis.
The mean follow-up of patients who did not develop metastasis was 81.81 months (median: 75 months) versus 42.14 months (median: 44 months) for patients with metastasis.
Conclusions.
KAI1 is a promising candidate marker that may offer prognostic value in UM; it may also represent a therapeutic target in metastatic disease.
American Psychological Association (APA)
Maloney, Shawn C.& Fernandes, Bruno F.& Penteado, Rafaella Cleto& Antecka, Emilia& Bravo-Filho, Vasco& Sanft, Debra Meghan…[et al.]. 2013. Expression of the Metastasis Suppressor KAI1 in Uveal Melanoma. Journal of Ophthalmology،Vol. 2013, no. 2013, pp.1-4.
https://search.emarefa.net/detail/BIM-490295
Modern Language Association (MLA)
Maloney, Shawn C.…[et al.]. Expression of the Metastasis Suppressor KAI1 in Uveal Melanoma. Journal of Ophthalmology No. 2013 (2013), pp.1-4.
https://search.emarefa.net/detail/BIM-490295
American Medical Association (AMA)
Maloney, Shawn C.& Fernandes, Bruno F.& Penteado, Rafaella Cleto& Antecka, Emilia& Bravo-Filho, Vasco& Sanft, Debra Meghan…[et al.]. Expression of the Metastasis Suppressor KAI1 in Uveal Melanoma. Journal of Ophthalmology. 2013. Vol. 2013, no. 2013, pp.1-4.
https://search.emarefa.net/detail/BIM-490295
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-490295