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Regulation of Hepatic Paraoxonase-1 Expression
Author
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-03
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Serum paraoxonase-1 (PON1) is a member of the paraoxonases family (PON1, PON2, and PON3).
PON1 is synthesized and secreted by the liver, and in circulation it is associated with HDL.
PON1 has antioxidative properties, which are associated with the enzyme’s capability to decrease oxidative stress in atherosclerotic lesions and to attenuate atherosclerosis development.
Epidemiological evidence demonstrates that low PON1 activity is associated with increased risk of cardiovascular events and cardiovascular disease and is an independent risk factor for coronary artery disease.
Therefore, pharmacological modulation of PON1 activity or PON1 gene expression could constitute a useful approach for preventing atherosclerosis.
A primary determinant of serum PON1 levels is the availability of the enzyme for release by the liver, the principal site of PON1 production.
Together with the enzyme secretion rate, enzymatic turnover, and protein stability, the level of PON1 gene expression is a major determinant of PON1 status.
This paper summarizes recent progress in understanding the regulation of PON1 expression in hepatocytes.
American Psychological Association (APA)
Fuhrman, Bianca. 2012. Regulation of Hepatic Paraoxonase-1 Expression. Journal of Lipids،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-490302
Modern Language Association (MLA)
Fuhrman, Bianca. Regulation of Hepatic Paraoxonase-1 Expression. Journal of Lipids No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-490302
American Medical Association (AMA)
Fuhrman, Bianca. Regulation of Hepatic Paraoxonase-1 Expression. Journal of Lipids. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-490302
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-490302