Molecular Dermatopathology in Malignant Melanoma
Joint Authors
Quatresooz, Pascale
Piérard, Gérald E.
Reginster, Marie-Annick
Piérard-Franchimont, Claudine
Source
Dermatology Research and Practice
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-20
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
At present, immunohistochemistry is taken for granted in the establishment of malignant melanoma (MM) diagnosis.
In recent years, molecular diagnosis in dermatopathology has benefited from a vast array of advances in the fields of genomics and proteomics.
Sensitive techniques are available for detecting specific DNA and RNA sequences by molecular hybridization.
This paper intends to update methods of molecular cytogenetics available as diagnostic adjuncts in the field of MM.
Cytogenetics has highlighted the pathogenesis of atypical melanocytic neoplasms with emphasis on the activation of the mitogen-activated protein kinase (MAPK) signalling pathway during the initiation step of the neoplasms.
20 to 40% of MM families have mutations in the tumour suppressor gene p16 or CDKN2A.
In addition, somatic mutations in p16, p53, BRAF, and cKIT are present in MM.
Genome-wide scan analyses on MM indicate positive associations for genes involved in melanocytic naevi, but MM is likely caused by a variety of common low-penetrance genes.
Molecular dermatopathology is expanding, and its use in the assessment of melanocytic neoplasms appears to be promising in the fields of research and diagnosis.
Molecular dermatopathology will probably make its way to an increased number of diagnostic laboratories.
The expected benefit should improve the patient management.
This evolution points to a need for evolution in the training requirements and role of dermatopathologists.
American Psychological Association (APA)
Reginster, Marie-Annick& Piérard-Franchimont, Claudine& Piérard, Gérald E.& Quatresooz, Pascale. 2011. Molecular Dermatopathology in Malignant Melanoma. Dermatology Research and Practice،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-490306
Modern Language Association (MLA)
Reginster, Marie-Annick…[et al.]. Molecular Dermatopathology in Malignant Melanoma. Dermatology Research and Practice No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-490306
American Medical Association (AMA)
Reginster, Marie-Annick& Piérard-Franchimont, Claudine& Piérard, Gérald E.& Quatresooz, Pascale. Molecular Dermatopathology in Malignant Melanoma. Dermatology Research and Practice. 2011. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-490306
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-490306