Functional Role of PPARs in Ruminants : Potential Targets for Fine-Tuning Metabolism during Growth and Lactation
Joint Authors
Bionaz, Massimo
Loor, Juan J.
Khan, Muhammad J.
Chen, Shuowen
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-28, 28 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-04-29
Country of Publication
Egypt
No. of Pages
28
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Characterization and biological roles of the peroxisome proliferator-activated receptor (PPAR) isotypes are well known in monogastrics, but not in ruminants.
However, a wealth of information has accumulated in little more than a decade on ruminant PPARs including isotype tissue distribution, response to synthetic and natural agonists, gene targets, and factors affecting their expression.
Functional characterization demonstrated that, as in monogastrics, the PPAR isotypes control expression of genes involved in lipid metabolism, anti-inflammatory response, development, and growth.
Contrary to mouse, however, the PPARγ gene network appears to controls milk fat synthesis in lactating ruminants.
As in monogastrics, PPAR isotypes in ruminants are activated by long-chain fatty acids, therefore, making them ideal candidates for fine-tuning metabolism in this species via nutrients.
In this regard, using information accumulated in ruminants and monogastrics, we propose a model of PPAR isotype-driven biological functions encompassing key tissues during the peripartal period in dairy cattle.
American Psychological Association (APA)
Bionaz, Massimo& Chen, Shuowen& Khan, Muhammad J.& Loor, Juan J.. 2013. Functional Role of PPARs in Ruminants : Potential Targets for Fine-Tuning Metabolism during Growth and Lactation. PPAR Research،Vol. 2013, no. 2013, pp.1-28.
https://search.emarefa.net/detail/BIM-490321
Modern Language Association (MLA)
Bionaz, Massimo…[et al.]. Functional Role of PPARs in Ruminants : Potential Targets for Fine-Tuning Metabolism during Growth and Lactation. PPAR Research No. 2013 (2013), pp.1-28.
https://search.emarefa.net/detail/BIM-490321
American Medical Association (AMA)
Bionaz, Massimo& Chen, Shuowen& Khan, Muhammad J.& Loor, Juan J.. Functional Role of PPARs in Ruminants : Potential Targets for Fine-Tuning Metabolism during Growth and Lactation. PPAR Research. 2013. Vol. 2013, no. 2013, pp.1-28.
https://search.emarefa.net/detail/BIM-490321
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-490321