Mitochondrial Oxidative Stress due to Complex I Dysfunction Promotes Fibroblast Activation and Melanoma Cell Invasiveness
Joint Authors
Sardanelli, Anna Maria
Giannoni, Elisa
Chiarugi, Paola
Scacco, Salvatore
Papa, Sergio
Taddei, Maria Letizia
Raugei, Giovanni
Source
Journal of Signal Transduction
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-01-04
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Increased ROS (cellular reactive oxygen species) are characteristic of both fibrosis and tumour development.
ROS induce the trans-differentiation to myofibroblasts, the activated form of fibroblasts able to promote cancer progression.
Here, we report the role of ROS produced in response to dysfunctions of mitochondrial complex I, in fibroblast activation and in tumour progression.
We studied human fibroblasts with mitochondrial dysfunctions of complex I, leading to hyperproduction of ROS.
We demonstrated that ROS level produced by the mutated fibroblasts correlates with their activation.
The increase of ROS in these cells provides a greater ability to remodel the extracellular matrix leading to an increased motility and invasiveness.
Furthermore, we evidentiated that in hypoxic conditions these fibroblasts cause HIF-1α stabilization and promote a proinvasive phenotype of human melanoma cells through secretion of cytokines.
These data suggest a possible role of deregulated mitochondrial ROS production in fibrosis evolution as well as in cancer progression and invasion.
American Psychological Association (APA)
Taddei, Maria Letizia& Giannoni, Elisa& Raugei, Giovanni& Scacco, Salvatore& Sardanelli, Anna Maria& Papa, Sergio…[et al.]. 2012. Mitochondrial Oxidative Stress due to Complex I Dysfunction Promotes Fibroblast Activation and Melanoma Cell Invasiveness. Journal of Signal Transduction،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-490363
Modern Language Association (MLA)
Taddei, Maria Letizia…[et al.]. Mitochondrial Oxidative Stress due to Complex I Dysfunction Promotes Fibroblast Activation and Melanoma Cell Invasiveness. Journal of Signal Transduction No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-490363
American Medical Association (AMA)
Taddei, Maria Letizia& Giannoni, Elisa& Raugei, Giovanni& Scacco, Salvatore& Sardanelli, Anna Maria& Papa, Sergio…[et al.]. Mitochondrial Oxidative Stress due to Complex I Dysfunction Promotes Fibroblast Activation and Melanoma Cell Invasiveness. Journal of Signal Transduction. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-490363
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-490363