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Casein Kinase Iγ2 Impairs Fibroblasts Actin Stress Fibers Formation and Delays Cell Cycle Progression in G1
Joint Authors
Abu-Thuraia, Afnan
Larose, Louise
Zuo, Dongmei
Oliva, Rossella
Latreille, Mathieu
Source
International Journal of Cell Biology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-07
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Actin cytoskeleton remodeling is under the regulation of multiple proteins with various activities.
Here, we demonstrate that the γ2 isoform of Casein Kinase I (CKIγ2) is part of a novel molecular path regulating the formation of actin stress fibers.
We show that overexpression of CKIγ2 in fibroblasts alters cell morphology by impairing actin stress fibers formation.
We demonstrate that this is concomitant with increased phosphorylation of the CDK inhibitor p27Kip and lower levels of activated RhoA, and is dependent on CKIγ2 catalytic activity.
Moreover, we report that roscovitine, a potent inhibitor of cyclin-dependent kinases, including Cdk5, decreases p27Kip protein levels and restores actin stress fibers formation in CKIγ2 overexpressing cells, suggesting the existence of a CKIγ2-Cdk5-p27Kip-RhoA pathway in regulating actin remodeling.
On the other hand, we also show that in a manner independent of its catalytic activity, CKIγ2 delays cell cycle progression through G1.
Collectively our findings reveal that CKIγ2 is a novel player in the control of actin cytoskeleton dynamics and cell proliferation.
American Psychological Association (APA)
Latreille, Mathieu& Abu-Thuraia, Afnan& Oliva, Rossella& Zuo, Dongmei& Larose, Louise. 2012. Casein Kinase Iγ2 Impairs Fibroblasts Actin Stress Fibers Formation and Delays Cell Cycle Progression in G1. International Journal of Cell Biology،Vol. 2012, no. 2012, pp.1-15.
https://search.emarefa.net/detail/BIM-490369
Modern Language Association (MLA)
Latreille, Mathieu…[et al.]. Casein Kinase Iγ2 Impairs Fibroblasts Actin Stress Fibers Formation and Delays Cell Cycle Progression in G1. International Journal of Cell Biology No. 2012 (2012), pp.1-15.
https://search.emarefa.net/detail/BIM-490369
American Medical Association (AMA)
Latreille, Mathieu& Abu-Thuraia, Afnan& Oliva, Rossella& Zuo, Dongmei& Larose, Louise. Casein Kinase Iγ2 Impairs Fibroblasts Actin Stress Fibers Formation and Delays Cell Cycle Progression in G1. International Journal of Cell Biology. 2012. Vol. 2012, no. 2012, pp.1-15.
https://search.emarefa.net/detail/BIM-490369
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-490369