Antidepressant Treatment for Acute Bipolar Depression : An Update
Joint Authors
Source
Depression Research and Treatment
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-01-27
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
While studies in the past have focused more on treatment of the manic phase of bipolar disorder (BD), recent findings demonstrate the depressive phase to be at least as debilitating.
However, in contrast to unipolar depression, depression in bipolar patients exhibits a varying response to antidepressants, raising questions regarding their efficacy and tolerability.
Methods.
We conducted a MEDLINE and Cochrane Collaboration Library search for papers published between 2005 and 2011 on the subject of antidepressant treatment of bipolar depression.
Sixty-eight articles were included in the present review.
Results.
While a few studies did advocate the use of antidepressants, most well-controlled studies failed to show a robust effect of antidepressants in bipolar depression, regardless of antidepressant class or bipolar subtype.
There was no significant increase in the rate of manic/hypomanic switch, especially with concurrent use of mood stabilizers.
Prescribing guidelines published in recent years rely more on atypical antipsychotics, especially quetiapine, as a first-line therapy.
Conclusions.
Antidepressants probably have no substantial role in acute bipolar depression.
However, in light of conflicting results between studies, more well-designed trials are warranted.
American Psychological Association (APA)
Amit, Ben H.& Weizman, Abraham. 2012. Antidepressant Treatment for Acute Bipolar Depression : An Update. Depression Research and Treatment،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-490373
Modern Language Association (MLA)
Amit, Ben H.& Weizman, Abraham. Antidepressant Treatment for Acute Bipolar Depression : An Update. Depression Research and Treatment No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-490373
American Medical Association (AMA)
Amit, Ben H.& Weizman, Abraham. Antidepressant Treatment for Acute Bipolar Depression : An Update. Depression Research and Treatment. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-490373
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-490373