Regional Variation on Rates of Bronchopulmonary Dysplasia and Associated Risk Factors
Joint Authors
Charry, Laura Patricia
Rondón, Martín Alonso
Rojas, Mario Augusto
Rojas, María Ximena
Lozano, Juan Manuel
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-05
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Pharmacy, Health & Medical Sciences
Pharmacology
Abstract EN
Background.
An abnormally high incidence (44%) of bronchopulmonary dysplasia with variations in rates among cities was observed in Colombia among premature infants.
Objective.
To identify risk factors that could explain the observed high incidence and regional variations of bronchopulmonary dysplasia.
Study Design.
A case-control study was designed for testing the hypothesis that differences in the disease rates were not explained by differences in city-of-birth specific population characteristics or by differences in respiratory management practices in the first 7 days of life, among cities.
Results.
Multivariate analysis showed that premature rupture of membranes, exposure to mechanical ventilation after received nasal CPAP, no surfactant exposure, use of rescue surfactant (instead of early surfactant), PDA, sepsis and the median daily FIO2, were associated with a higher risk of dysplasia.
Significant differences between cases and controls were found among cities.
Models exploring for associations between city of birth and dysplasia showed that being born in the highest altitude city (Bogotá) was associated with a higher risk of dysplasia (OR 1.82 95% CI 1.31–2.53).
Conclusions.
Bronchopulmonary dysplasia was manly explained by traditional risk factors.
Findings suggest that altitude may play an important role in the development of this disease.
Prenatal steroids did not appear to be protective at high altitude.
American Psychological Association (APA)
Rojas, María Ximena& Rojas, Mario Augusto& Lozano, Juan Manuel& Rondón, Martín Alonso& Charry, Laura Patricia. 2012. Regional Variation on Rates of Bronchopulmonary Dysplasia and Associated Risk Factors. ISRN Pediatrics،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-490424
Modern Language Association (MLA)
Rojas, María Ximena…[et al.]. Regional Variation on Rates of Bronchopulmonary Dysplasia and Associated Risk Factors. ISRN Pediatrics No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-490424
American Medical Association (AMA)
Rojas, María Ximena& Rojas, Mario Augusto& Lozano, Juan Manuel& Rondón, Martín Alonso& Charry, Laura Patricia. Regional Variation on Rates of Bronchopulmonary Dysplasia and Associated Risk Factors. ISRN Pediatrics. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-490424
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-490424