Role of the Renin-Angiotensin System and Aldosterone on Cardiometabolic Syndrome
Joint Authors
Vallejo-Vaz, A. J.
García-Morillo, S.
Villar, J.
Stiefel García-Junco, P.
Source
International Journal of Hypertension
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-23
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Aldosterone facilitates cardiovascular damage by increasing blood pressure and through different mechanisms that are independent of its effects on blood pressure.
In this respect, recent evidence involves aldosterone in the pathogenesis of metabolic syndrome.
Although this relationship is complex, there is some evidence suggesting that different factors may play an important role, such as insulin resistance, renin-angiotensin-aldosterone system, oxidative stress, sodium retention, increased sympathetic activity, levels of free fatty acids, or inflammatory cytokines and adipokines.
In addition to the classical pathway by which aldosterone acts through the mineralocorticoid receptors leading to sodium retention, aldosterone also has other mechanisms that influence cardiovascular tissue remodelling.
Finally, overweight and obesity promote the adrenal secretion of aldosterone, increasing the predisposition to type 2 diabetes mellitus.
Further studies are needed to better establish therapeutic strategies that act on the blockade of mineralocorticoid receptor in the treatment and prevention of cardiovascular diseases related to the excess of aldosterone and the metabolic syndrome.
American Psychological Association (APA)
Stiefel García-Junco, P.& Vallejo-Vaz, A. J.& García-Morillo, S.& Villar, J.. 2011. Role of the Renin-Angiotensin System and Aldosterone on Cardiometabolic Syndrome. International Journal of Hypertension،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-490433
Modern Language Association (MLA)
Stiefel García-Junco, P.…[et al.]. Role of the Renin-Angiotensin System and Aldosterone on Cardiometabolic Syndrome. International Journal of Hypertension No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-490433
American Medical Association (AMA)
Stiefel García-Junco, P.& Vallejo-Vaz, A. J.& García-Morillo, S.& Villar, J.. Role of the Renin-Angiotensin System and Aldosterone on Cardiometabolic Syndrome. International Journal of Hypertension. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-490433
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-490433