Hematopoietic Stem Cell Mobilization and Homing after Transplantation : The Role of MMP-2, MMP-9, and MT1-MMP
Joint Authors
Marquez-Curtis, Leah A.
Janowska-Wieczorek, Anna
Shirvaikar, Neeta
Source
Biochemistry Research International
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-04
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Hematopoietic stem/progenitor cells (HSPCs) are used in clinical transplantation to restore hematopoietic function.
Here we review the role of the soluble matrix metalloproteinases MMP-2 and MMP-9, and membrane type (MT)1-MMP in modulating processes critical to successful transplantation of HSPC, such as mobilization and homing.
Growth factors and cytokines which are employed as mobilizing agents upregulate MMP-2 and MMP-9.
Recently we demonstrated that MT1-MMP enhances HSPC migration across reconstituted basement membrane, activates proMMP-2, and contributes to a highly proteolytic bone marrow microenvironment that facilitates egress of HSPC.
On the other hand, we reported that molecules secreted during HSPC mobilization and collection, such as hyaluronic acid and thrombin, increase MT1-MMP expression in cord blood HSPC and enhance (prime) their homing-related responses.
We suggest that modulation of MMP-2, MMP-9, and MT1-MMP expression has potential for development of new therapies for more efficient mobilization, homing, and engraftment of HSPC, which could lead to improved transplantation outcomes.
American Psychological Association (APA)
Shirvaikar, Neeta& Marquez-Curtis, Leah A.& Janowska-Wieczorek, Anna. 2012. Hematopoietic Stem Cell Mobilization and Homing after Transplantation : The Role of MMP-2, MMP-9, and MT1-MMP. Biochemistry Research International،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-490439
Modern Language Association (MLA)
Shirvaikar, Neeta…[et al.]. Hematopoietic Stem Cell Mobilization and Homing after Transplantation : The Role of MMP-2, MMP-9, and MT1-MMP. Biochemistry Research International No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-490439
American Medical Association (AMA)
Shirvaikar, Neeta& Marquez-Curtis, Leah A.& Janowska-Wieczorek, Anna. Hematopoietic Stem Cell Mobilization and Homing after Transplantation : The Role of MMP-2, MMP-9, and MT1-MMP. Biochemistry Research International. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-490439
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-490439