Optimal Treatment Strategies for HIV with Antibody Response
Joint Authors
Zhou, Kai
Zhou, Yinggao
Wang, Chunling
Yang, Kuan
Source
Journal of Applied Mathematics
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-10
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Numerical analysis and optimization tools are used to suggest improved therapies to try and cure HIV infection.
An HIV model of ordinary differential equation, which includes immune response, neutralizing antibodies, and multidrug effects, is improved.
For a fixed time, single-drug and two-drug treatment strategies are explored based on Pontryagin’s maximum principle.
Using different combinations of weight factor pairs combining with special upper-bound pairs for controls, nine types of treatment policies are determined and different therapy effects are numerically simulated with a gradient projection method.
Some strategies are effective, but some strategies are not particularly helpful for the therapy of HIV/AIDS.
Comparing the effective treatment strategies, we find a more appropriate strategy with maximizing the number of uninfected CD4+T-cells and minimizing the number of active virus.
American Psychological Association (APA)
Zhou, Yinggao& Yang, Kuan& Zhou, Kai& Wang, Chunling. 2014. Optimal Treatment Strategies for HIV with Antibody Response. Journal of Applied Mathematics،Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-490443
Modern Language Association (MLA)
Zhou, Yinggao…[et al.]. Optimal Treatment Strategies for HIV with Antibody Response. Journal of Applied Mathematics No. 2014 (2014), pp.1-13.
https://search.emarefa.net/detail/BIM-490443
American Medical Association (AMA)
Zhou, Yinggao& Yang, Kuan& Zhou, Kai& Wang, Chunling. Optimal Treatment Strategies for HIV with Antibody Response. Journal of Applied Mathematics. 2014. Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-490443
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-490443