Antidiabetic Effect and Mode of Action of Cytopiloyne
Joint Authors
Liu, Hsien-Yueh
Chang, Cicero Lee-Tian
Pan, Chien-Yuan
Shen, Ming-Yi
Hsu, Yi-Jou
Yang, Wen-Chin
Kuo, Tien-Fen
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-03-13
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Cytopiloyne was identified as a novel polyacetylenic compound.
However, its antidiabetic properties are poorly understood.
The aim of the present study was to investigate the anti-diabetic effect and mode of action of cytopiloyne on type 2 diabetes (T2D).
We first evaluated the therapeutic effect of cytopiloyne on T2D in db/db mice.
We found that one dose of cytopiloyne reduced postprandial glucose levels while increasing blood insulin levels.
Accordingly, long-term treatment with cytopiloyne reduced postprandial blood glucose levels, increased blood insulin, improved glucose tolerance, suppressed the level of glycosylated hemoglobin A1c (HbA1c), and protected pancreatic islets in db/db mice.
Next, we studied the anti-diabetic mechanism of action of cytopiloyne.
We showed that cytopiloyne failed to decrease blood glucose in streptozocin- (STZ-)treated mice whose β cells were already destroyed.
Additionally, cytopiloyne dose dependently increased insulin secretion and expression in β cells.
The increase of insulin secretion/expression of cytopiloyne was regulated by protein kinase Cα (PKCα) and its activators, calcium, and diacylglycerol (DAG).
Overall, our data suggest that cytopiloyne treats T2D via regulation of insulin production involving the calcium/DAG/PKCα cascade in β cells.
These data thus identify the molecular mechanism of action of cytopiloyne and prove its therapeutic potential in T2D.
American Psychological Association (APA)
Chang, Cicero Lee-Tian& Liu, Hsien-Yueh& Kuo, Tien-Fen& Hsu, Yi-Jou& Shen, Ming-Yi& Pan, Chien-Yuan…[et al.]. 2013. Antidiabetic Effect and Mode of Action of Cytopiloyne. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-490473
Modern Language Association (MLA)
Chang, Cicero Lee-Tian…[et al.]. Antidiabetic Effect and Mode of Action of Cytopiloyne. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-13.
https://search.emarefa.net/detail/BIM-490473
American Medical Association (AMA)
Chang, Cicero Lee-Tian& Liu, Hsien-Yueh& Kuo, Tien-Fen& Hsu, Yi-Jou& Shen, Ming-Yi& Pan, Chien-Yuan…[et al.]. Antidiabetic Effect and Mode of Action of Cytopiloyne. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-490473
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-490473