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Apoptosis : Reprogramming and the Fate of Mature Cells
Joint Authors
Liu, Xiaozhuo
Rennert, Owen M.
Cheung, Hoi-Hung
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-17
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Apoptosis is essential for embryogenesis, organ metamorphosis, and tissue homeostasis.
In embryonic stem cells, self-renewal is balanced with proliferative potential, inhibition of differentiation, and prevention of senescence and apoptosis.
Growing evidence supports the role of apoptosis in self-renewal, differentiation of pluripotent stem cells, and dedifferentiation (reprogramming) of somatic cells.
In this paper we discuss the multiple roles of apoptosis in embryonic stem cells (ESCs) and reprogramming of differentiated cells to pluripotency.
The role of caspases and p53 as key effectors in controlling the generation of iPSC is emphasized.
Remarkably, the complication of apoptosis arising during reprogramming may provide insights into technical improvements for derivation of iPSC from senescent cells as a tool for modeling aging-related diseases.
American Psychological Association (APA)
Cheung, Hoi-Hung& Liu, Xiaozhuo& Rennert, Owen M.. 2012. Apoptosis : Reprogramming and the Fate of Mature Cells. ISRN Cell Biology،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-490491
Modern Language Association (MLA)
Cheung, Hoi-Hung…[et al.]. Apoptosis : Reprogramming and the Fate of Mature Cells. ISRN Cell Biology No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-490491
American Medical Association (AMA)
Cheung, Hoi-Hung& Liu, Xiaozhuo& Rennert, Owen M.. Apoptosis : Reprogramming and the Fate of Mature Cells. ISRN Cell Biology. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-490491
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-490491