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Helicobacter pylori Eradication Lowers Serum Asymmetric Dimethylarginine Levels
Joint Authors
Aydemir, Selim
Harmandar, Ferda Akbay
Demircan, Nejat
Tekin, Ishak Ozel
Eren, Hacı
Cabuk, Mehmet
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-12-13
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Introduction.
Microbial pathogens, one of them is Helicobacter pylori (H.
pylori), have frequently been implicated in the atherogenesis.
Endothelium-derived nitric oxide (NO) is synthesized from L-arginine by nitric oxide synthase (NOS) and plays a pivotal role in the regulation of vascular tone.
Asymmetric dimethylarginine (ADMA) is the most potent endogenous NOS inhibitor.
Elevated levels of ADMA have been reported in many circumstances associated with a high cardiovascular risk.
The aim of the present study was to investigate whether the eradication of H.
pylori infection affects serum ADMA levels.
Materials and Methods.
Forty-two H.
pylori-positive patients were enrolled in the study.
Triple therapy for 14 days were given to all patients.
Serum ADMA levels were measured at baseline and 2 months after therapy.
Results.
Eradication was achieved in 34 (81%) patients.
The mean serum ADMA levels before and after therapy were 1,77±0,30 and 1,67±0,29 ng/mL in the group with H.
pylori eradicated and 1,63±0,28 and 1,56±0,32 ng/mL in the noneradicated, respectively.
We detected statistically significant decreased serum ADMA levels after therapy in H.
pylori eradicated group.
Conclusion.
These findings have indicated that eradication of H.
pylori infection may decrease the risk of atherosclerosis and cardiovascular events.
American Psychological Association (APA)
Aydemir, Selim& Eren, Hacı& Tekin, Ishak Ozel& Harmandar, Ferda Akbay& Demircan, Nejat& Cabuk, Mehmet. 2010. Helicobacter pylori Eradication Lowers Serum Asymmetric Dimethylarginine Levels. Mediators of Inflammation،Vol. 2010, no. 2010, pp.1-4.
https://search.emarefa.net/detail/BIM-490494
Modern Language Association (MLA)
Aydemir, Selim…[et al.]. Helicobacter pylori Eradication Lowers Serum Asymmetric Dimethylarginine Levels. Mediators of Inflammation No. 2010 (2010), pp.1-4.
https://search.emarefa.net/detail/BIM-490494
American Medical Association (AMA)
Aydemir, Selim& Eren, Hacı& Tekin, Ishak Ozel& Harmandar, Ferda Akbay& Demircan, Nejat& Cabuk, Mehmet. Helicobacter pylori Eradication Lowers Serum Asymmetric Dimethylarginine Levels. Mediators of Inflammation. 2010. Vol. 2010, no. 2010, pp.1-4.
https://search.emarefa.net/detail/BIM-490494
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-490494