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p16, Cyclin D1, and HIF-1α Predict Outcomes of Patients with Oropharyngeal Squamous Cell Carcinoma Treated with Definitive Intensity-Modulated Radiation Therapy
Joint Authors
Read, Paul W.
Levine, Paul A.
Stelow, Edward B.
Reibel, James F.
Saylor, Drew K.
Wilson, David D.
Jameson, Mark J.
Rahimi, Asal S.
Thomas, Christopher Y.
Shonka, David C.
Source
International Journal of Otolaryngology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-24
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
We evaluated a panel of 8 immunohistochemical biomarkers as predictors of clinical response to definitive intensity-modulated radiotherapy in patients with oropharyngeal squamous cell carcinoma (OPSCC).
106 patients with OPSCC were treated to a total dose of 66–70 Gy and retrospectively analyzed for locoregional control (LRC), disease-free survival (DFS), and overall survival (OS).
All tumors had p16 immunohistochemical staining, and 101 tumors also had epidermal growth factor receptor (EGFR) staining.
53% of the patients had sufficient archived pathologic specimens for incorporation into a tissue microarray for immunohistochemical analysis for cyclophilin B, cyclin D1, p21, hypoxia-inducible factor-1α (HIF-1α), carbonic anhydrase, and major vault protein.
Median followup was 27.2 months.
66% of the tumors were p16 positive, and 34% were p16 negative.
On univariate analysis, the following correlations were statistically significant: p16 positive staining with higher LRC (P=0.005) and longer DFS (P<0.001); cyclin D1 positive staining with lower LRC (P=0.033) and shorter DFS (P=0.002); HIF-1α positive staining with shorter DFS (P=0.039).
On multivariate analysis, p16 was the only significant independent predictor of DFS (P=0.023).
After immunohistochemical examination of a panel of 8 biomarkers, our study could only verify p16 as an independent prognostic factor in OPSCC.
American Psychological Association (APA)
Rahimi, Asal S.& Wilson, David D.& Saylor, Drew K.& Stelow, Edward B.& Thomas, Christopher Y.& Reibel, James F.…[et al.]. 2012. p16, Cyclin D1, and HIF-1α Predict Outcomes of Patients with Oropharyngeal Squamous Cell Carcinoma Treated with Definitive Intensity-Modulated Radiation Therapy. International Journal of Otolaryngology،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-490503
Modern Language Association (MLA)
Rahimi, Asal S.…[et al.]. p16, Cyclin D1, and HIF-1α Predict Outcomes of Patients with Oropharyngeal Squamous Cell Carcinoma Treated with Definitive Intensity-Modulated Radiation Therapy. International Journal of Otolaryngology No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-490503
American Medical Association (AMA)
Rahimi, Asal S.& Wilson, David D.& Saylor, Drew K.& Stelow, Edward B.& Thomas, Christopher Y.& Reibel, James F.…[et al.]. p16, Cyclin D1, and HIF-1α Predict Outcomes of Patients with Oropharyngeal Squamous Cell Carcinoma Treated with Definitive Intensity-Modulated Radiation Therapy. International Journal of Otolaryngology. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-490503
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-490503