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Cationic Albumin Nanoparticles for Enhanced Drug Delivery to Treat Breast Cancer : Preparation and In Vitro Assessment
Joint Authors
Prakash, Satya
Shao, Wei
Paul, Arghya
Abbasi, Sana
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-12-08
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Most anticancer drugs are greatly limited by the serious side effects that they cause.
Doxorubicin (DOX) is an antineoplastic agent, commonly used against breast cancer.
However, it may lead to irreversible cardiotoxicity, which could even result in congestive heart failure.
In order to avoid these harmful side effects to the patients and to improve the therapeutic efficacy of doxorubicin, we developed DOX-loaded polyethylenimine- (PEI-) enhanced human serum albumin (HSA) nanoparticles.
The formed nanoparticles were ~137 nm in size with a surface zeta potential of ~+15 mV, prepared using 20 μg of PEI added per mg of HSA.
Cytotoxicity was not observed with empty PEI-enhanced HSA nanoparticles, formed with low-molecular weight (25 kDa) PEI, indicating biocompatibility and safety of the nanoparticle formulation.
Under optimized transfection conditions, approximately 80% of cells were transfected with HSA nanoparticles containing tetramethylrhodamine-conjugated bovine serum albumin.
Conclusively, PEI-enhanced HSA nanoparticles show potential for developing into an effective carrier for anticancer drugs.
American Psychological Association (APA)
Abbasi, Sana& Paul, Arghya& Shao, Wei& Prakash, Satya. 2011. Cationic Albumin Nanoparticles for Enhanced Drug Delivery to Treat Breast Cancer : Preparation and In Vitro Assessment. Journal of Drug Delivery،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-490513
Modern Language Association (MLA)
Abbasi, Sana…[et al.]. Cationic Albumin Nanoparticles for Enhanced Drug Delivery to Treat Breast Cancer : Preparation and In Vitro Assessment. Journal of Drug Delivery No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-490513
American Medical Association (AMA)
Abbasi, Sana& Paul, Arghya& Shao, Wei& Prakash, Satya. Cationic Albumin Nanoparticles for Enhanced Drug Delivery to Treat Breast Cancer : Preparation and In Vitro Assessment. Journal of Drug Delivery. 2011. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-490513
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-490513