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Pharmacogenetics of Oral Antidiabetic Drugs
Joint Authors
Becker, Matthijs L.
Tkáč, Ivan
Pearson, Ewan R.
Source
International Journal of Endocrinology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-13
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Oral antidiabetic drugs (OADs) are used for more than a half-century in the treatment of type 2 diabetes.
Only in the last five years, intensive research has been conducted in the pharmacogenetics of these drugs based mainly on the retrospective register studies, but only a handful of associations detected in these studies were replicated.
The gene variants in CYP2C9, ABCC8/KCNJ11, and TCF7L2 were associated with the effect of sulfonylureas.
CYP2C9 encodes sulfonylurea metabolizing cytochrome P450 isoenzyme 2C9, ABCC8 and KCNJ11 genes encode proteins constituting ATP-sensitive K+ channel which is a therapeutic target for sulfonylureas, and TCF7L2 is a gene with the strongest association with type 2 diabetes.
SLC22A1, SLC47A1, and ATM gene variants were repeatedly associated with the response to metformin.
SLC22A1 and SLC47A1 encode metformin transporters OCT1 and MATE1, respectively.
The function of a gene variant near ATM gene identified by a genome-wide association study is not elucidated so far.
The first variant associated with the response to gliptins is a polymorphism in the proximity of CTRB1/2 gene which encodes chymotrypsinogen.
Establishment of diabetes pharmacogenetics consortia and reduction in costs of genomics might lead to some significant clinical breakthroughs in this field in a near future.
American Psychological Association (APA)
Becker, Matthijs L.& Pearson, Ewan R.& Tkáč, Ivan. 2013. Pharmacogenetics of Oral Antidiabetic Drugs. International Journal of Endocrinology،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-490536
Modern Language Association (MLA)
Becker, Matthijs L.…[et al.]. Pharmacogenetics of Oral Antidiabetic Drugs. International Journal of Endocrinology No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-490536
American Medical Association (AMA)
Becker, Matthijs L.& Pearson, Ewan R.& Tkáč, Ivan. Pharmacogenetics of Oral Antidiabetic Drugs. International Journal of Endocrinology. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-490536
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-490536