Efficacy and Cytokine Modulating Effects of Tacrolimus in Systemic Lupus Erythematosus : A Review
Author
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-06-28
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Systemic lupus erythematosus (SLE) is a complex systemic autoimmune disease with involvement of both B cells and cytotoxic T lymphocytes and several cytokines aberrations.
Standard therapy for SLE has its limitations.
Tacrolimus, a novel calcineurin inhibitor with potent immunosuppressive effects, has been shown in the recent years to be effective in SLE therapy.
This paper serves to collate the experimental and clinical data on the efficacy of tacrolimus in the treatment of SLE and lupus nephritis.
Tacrolimus as a key component of multitarget therapy in SLE is also discussed.
The immunocytokine modulatory effects of tacrolimus are also reviewed with reference to SLE.
It can be concluded that tacrolimus has an established role in the management of SLE.
American Psychological Association (APA)
Yoon, Kam Hon. 2010. Efficacy and Cytokine Modulating Effects of Tacrolimus in Systemic Lupus Erythematosus : A Review. Journal of Biomedicine and Biotechnology،Vol. 2010, no. 2010, pp.1-4.
https://search.emarefa.net/detail/BIM-490556
Modern Language Association (MLA)
Yoon, Kam Hon. Efficacy and Cytokine Modulating Effects of Tacrolimus in Systemic Lupus Erythematosus : A Review. Journal of Biomedicine and Biotechnology No. 2010 (2010), pp.1-4.
https://search.emarefa.net/detail/BIM-490556
American Medical Association (AMA)
Yoon, Kam Hon. Efficacy and Cytokine Modulating Effects of Tacrolimus in Systemic Lupus Erythematosus : A Review. Journal of Biomedicine and Biotechnology. 2010. Vol. 2010, no. 2010, pp.1-4.
https://search.emarefa.net/detail/BIM-490556
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-490556