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Molecular Implications of the PPARs in the Diabetic Eye
Joint Authors
Simó, Rafael
Ciudin, Andreea
Hernández, Cristina
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-02-04
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Diabetic retinopathy (DR) remains as the leading cause of blindness among working age individuals in developed countries.
Current treatments for DR (laser photocoagulation, intravitreal corticosteroids, intravitreal anti-VEGF agents, and vitreoretinal surgery) are applicable only at advanced stages of the disease and are associated with significant adverse effects.
Therefore, new pharmacological treatments for the early stages of the disease are needed.
Emerging evidence indicates that peroxisome proliferator-activator receptors (PPARs) agonists (in particular PPARα) are useful for the treatment of DR.
However, the underlying molecular mechanisms are far from being elucidated.
This paper mainly focuses on PPARs expression in the diabetic eye, its molecular implications, and the effect of PPAR agonists as a new approach for the treatment of DR.
The availability of this new strategy will not only be beneficial in treating DR but may also result in a shift towards treating earlier stages of diabetic retinopathy, thus easing the burden of this devastating disease (Cheung et al.
(2010)).
American Psychological Association (APA)
Ciudin, Andreea& Hernández, Cristina& Simó, Rafael. 2013. Molecular Implications of the PPARs in the Diabetic Eye. PPAR Research،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-490562
Modern Language Association (MLA)
Ciudin, Andreea…[et al.]. Molecular Implications of the PPARs in the Diabetic Eye. PPAR Research No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-490562
American Medical Association (AMA)
Ciudin, Andreea& Hernández, Cristina& Simó, Rafael. Molecular Implications of the PPARs in the Diabetic Eye. PPAR Research. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-490562
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-490562