Peripheral 5-HT 1A and 5-HT 7 Serotonergic Receptors Modulate Parasympathetic Neurotransmission in Long-Term Diabetic Rats
Joint Authors
Morán, Asunción
Restrepo, Beatriz
Martín, María Luisa
San Román, Luis
Source
Experimental Diabetes Research
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-02-17
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
We analyzed the modulation of serotonin on the bradycardia induced in vivo by vagal electrical stimulation in alloxan-induced long-term diabetic rats.
Bolus intravenous administration of serotonin had a dual effect on the bradycardia induced either by vagal stimulation or exogenous Ach, increasing it at low doses and decreasing it at high doses of 5-hydroxytryptamine (5-HT), effect reproduced by 5-carboxamidotryptamine maleate (5-CT), a 5-HT1/7 agonist.
The enhancement of the bradycardia at low doses of 5-CT was reproduced by 5-HT 1A agonist 8-hydroxy-2-dipropylaminotetralin hydrobromide (8-OH-DPAT) and abolished by WAY-100,635, 5-HT 1A antagonist.
Pretreatment with 5-HT1 antagonist methiothepin blocked the stimulatory and inhibitory effect of 5-CT, whereas pimozide, 5-HT7 antagonist, only abolished 5-CT inhibitory action.
In conclusion, long-term diabetes elicits changes in the subtype of the 5-HT receptor involved in modulation of vagally induced bradycardia.
Activation of the 5-HT 1A receptors induces enhancement, whereas attenuation is due to 5-HT7 receptor activation.
This 5-HT dual effect occurs at pre- and postjunctional levels.
American Psychological Association (APA)
Restrepo, Beatriz& Martín, María Luisa& San Román, Luis& Morán, Asunción. 2011. Peripheral 5-HT 1A and 5-HT 7 Serotonergic Receptors Modulate Parasympathetic Neurotransmission in Long-Term Diabetic Rats. Experimental Diabetes Research،Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-490572
Modern Language Association (MLA)
Restrepo, Beatriz…[et al.]. Peripheral 5-HT 1A and 5-HT 7 Serotonergic Receptors Modulate Parasympathetic Neurotransmission in Long-Term Diabetic Rats. Experimental Diabetes Research No. 2010 (2010), pp.1-10.
https://search.emarefa.net/detail/BIM-490572
American Medical Association (AMA)
Restrepo, Beatriz& Martín, María Luisa& San Román, Luis& Morán, Asunción. Peripheral 5-HT 1A and 5-HT 7 Serotonergic Receptors Modulate Parasympathetic Neurotransmission in Long-Term Diabetic Rats. Experimental Diabetes Research. 2011. Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-490572
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-490572