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Targeted Therapy of Ewing's Sarcoma
Joint Authors
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-10-31
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Refractory and/or recurrent Ewing's sarcoma (EWS) remains a clinical challenge because the disease's resistance to therapy makes it difficult to achieve durable results with standard treatments that include chemotherapy, radiation, and surgery.
Recently, insulin-like-growth-factor-1-receptor (IGF1R) antibodies have been shown to have a modest single-agent activity in EWS.
Patient selection using biomarkers and understanding response and resistance mechanisms in relation to IGF1R and mammalian target of rapamycin pathways are areas of active research.
Since EWS has a unique tumor-specific EWS-FLI1 t(11;22) translocation and oncogenic fusion protein, inhibition of EWS-FLI1 transcription, translation, and/or protein function may be key to eradicating EWS at the stem-cell level.
Recently, a small molecule that blocks the protein-protein interaction of EWS-FLI1 with RNA helicase A has been shown in preclinical models to inhibit EWS growth.
The successful application of this first-in-class protein-protein inhibitor in the clinic could become a model system for translocation-associated cancers such as EWS.
American Psychological Association (APA)
Subbiah, Vivek& Anderson, Peter. 2010. Targeted Therapy of Ewing's Sarcoma. Sarcoma،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-490595
Modern Language Association (MLA)
Subbiah, Vivek& Anderson, Peter. Targeted Therapy of Ewing's Sarcoma. Sarcoma No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-490595
American Medical Association (AMA)
Subbiah, Vivek& Anderson, Peter. Targeted Therapy of Ewing's Sarcoma. Sarcoma. 2010. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-490595
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-490595