Mitogenic Effects of Phosphatidylcholine Nanoparticles on MCF-7 Breast Cancer Cells
Joint Authors
Pérez, Sebastián E.
Sotelo, Ana I.
Carlucci, Adriana Mónica
Gándola, Yamila B.
Gonzalez, Lorena
Miquet, Johanna G.
Corradi, Gerardo R.
Irene, Pablo E.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-20
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Lecithins, mainly composed of the phospholipids phosphatidylcholines (PC), have many different uses in the pharmaceutical and clinical field.
PC are involved in structural and biological functions as membrane trafficking processes and cellular signaling.
Considering the increasing applications of lecithin-based nanosystems for the delivery of therapeutic agents, the aim of the present work was to determine the effects of phosphatidylcholine nanoparticles over breast cancer cellular proliferation and signaling.
PC dispersions at 0.01 and 0.1% (w/v) prepared in buffer pH 7.0 and 5.0 were studied in the MCF-7 breast cancer cell line.
Neutral 0.1% PC-derived nanoparticles induced the activation of the MEK-ERK1/2 pathway, increased cell viability and induced a 1.2 fold raise in proliferation.
These biological effects correlated with the increase of epidermal growth factor receptor (EGFR) content and its altered cellular localization.
Results suggest that nanoparticles derived from PC dispersion prepared in buffer pH 7.0 may induce physicochemical changes in the plasma membrane of cancer cells which may affect EGFR cellular localization and/or activity, increasing activation of the MEK-ERK1/2 pathway and inducing proliferation.
Results from the present study suggest that possible biological effects of delivery systems based on lecithin nanoparticles should be taken into account in pharmaceutical formulation design.
American Psychological Association (APA)
Gándola, Yamila B.& Pérez, Sebastián E.& Irene, Pablo E.& Sotelo, Ana I.& Miquet, Johanna G.& Corradi, Gerardo R.…[et al.]. 2014. Mitogenic Effects of Phosphatidylcholine Nanoparticles on MCF-7 Breast Cancer Cells. BioMed Research International،Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-490598
Modern Language Association (MLA)
Gándola, Yamila B.…[et al.]. Mitogenic Effects of Phosphatidylcholine Nanoparticles on MCF-7 Breast Cancer Cells. BioMed Research International No. 2014 (2014), pp.1-13.
https://search.emarefa.net/detail/BIM-490598
American Medical Association (AMA)
Gándola, Yamila B.& Pérez, Sebastián E.& Irene, Pablo E.& Sotelo, Ana I.& Miquet, Johanna G.& Corradi, Gerardo R.…[et al.]. Mitogenic Effects of Phosphatidylcholine Nanoparticles on MCF-7 Breast Cancer Cells. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-490598
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-490598