Benzylthiouracil-Induced Glomerulonephritis
Joint Authors
Trimeche Ajmi, Sihem
Maaroufi, Amel
Toumi, Sarra
Ach, Koussay
Chadli Chaieb, Molka
Chaieb, Larbi
Braham, Rim
Source
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-07-06
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Vasculitis is a rare complication of antithyroid drugs (ATDs).
It was first described with Propylthiouracil (PTU).
We report a new case of antineutrophil cytoplasmic antibody (ANCA) vasculitis with glomerulonephritis induced by Benzylthiouracile (BTU).
A 50-year-old man with Graves disease treated with BTU developed general malaise and haematuria without skin rash or respiratory involvement.
Laboratory data revealed acute renal failure with proteinuria and haematuria.
An indirect immunofluorescence test for ANCA was positive, showing a perinuclear pattern with specificity antimyeloperoxidase (MPO).
A renal biopsy was performed and revealed pauci-immune extracapillary glomerular nephropathy and necrotic vasculitis lesions.
Based on these findings we concluded to the diagnosis of rapidly progressive glomerulonephritis associated with ANCA induced by BTU therapy.
The drug was therefore discontinued and the patient was treated with steroids and immunosuppressive treatment during 3 months.
Renal failure, proteinuria and haematuria significantly improved within 2 months.
However, P-ANCA remained positive until 10 months after drug withdrawal.
Thyroid function was kept within normal range using iodine solution.
We demonstrated clearly that BTU may induce severe forms of vasculitis with glomerulonephritis.
Thus, the ANCA must be measured when confronted to systemic manifestation during treatment.
American Psychological Association (APA)
Trimeche Ajmi, Sihem& Braham, Rim& Toumi, Sarra& Chadli Chaieb, Molka& Maaroufi, Amel& Ach, Koussay…[et al.]. 2009. Benzylthiouracil-Induced Glomerulonephritis. Case Reports in Medicine،Vol. 2009, no. 2009, pp.1-4.
https://search.emarefa.net/detail/BIM-490628
Modern Language Association (MLA)
Trimeche Ajmi, Sihem…[et al.]. Benzylthiouracil-Induced Glomerulonephritis. Case Reports in Medicine No. 2009 (2009), pp.1-4.
https://search.emarefa.net/detail/BIM-490628
American Medical Association (AMA)
Trimeche Ajmi, Sihem& Braham, Rim& Toumi, Sarra& Chadli Chaieb, Molka& Maaroufi, Amel& Ach, Koussay…[et al.]. Benzylthiouracil-Induced Glomerulonephritis. Case Reports in Medicine. 2009. Vol. 2009, no. 2009, pp.1-4.
https://search.emarefa.net/detail/BIM-490628
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-490628