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PPARG Epigenetic Deregulation and Its Role in Colorectal Tumorigenesis
Joint Authors
Sabatino, Lina
Colantuoni, Vittorio
Pancione, Massimo
Fucci, Alessandra
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-16
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Peroxisome proliferator-activated receptor gamma (PPARγ) plays critical roles in lipid storage, glucose metabolism, energy homeostasis, adipocyte differentiation, inflammation, and cancer.
Its function in colon carcinogenesis has largely been debated; accumulating evidence, however, supports a role as tumor suppressor through modulation of crucial pathways in cell differentiation, apoptosis, and metastatic dissemination.
Epigenetics adds a further layer of complexity to gene regulation in several biological processes.
In cancer, the relationship with epigenetic modifications has provided important insights into the underlying molecular mechanisms.
These studies have highlighted how epigenetic modifications influence PPARG gene expression in colorectal tumorigenesis.
In this paper, we take a comprehensive look at the current understanding of the relationship between PPARγ and cancer development.
The role that epigenetic mechanisms play is also addressed disclosing novel crosstalks between PPARG signaling and the epigenetic machinery and suggesting how this dysregulation may contribute to colon cancer development.
American Psychological Association (APA)
Sabatino, Lina& Fucci, Alessandra& Pancione, Massimo& Colantuoni, Vittorio. 2012. PPARG Epigenetic Deregulation and Its Role in Colorectal Tumorigenesis. PPAR Research،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-490648
Modern Language Association (MLA)
Sabatino, Lina…[et al.]. PPARG Epigenetic Deregulation and Its Role in Colorectal Tumorigenesis. PPAR Research No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-490648
American Medical Association (AMA)
Sabatino, Lina& Fucci, Alessandra& Pancione, Massimo& Colantuoni, Vittorio. PPARG Epigenetic Deregulation and Its Role in Colorectal Tumorigenesis. PPAR Research. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-490648
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-490648