Epigenetic Markers of Renal Function in African Americans
Joint Authors
Taylor, Jacquelyn Y.
Smith, Jennifer A.
Kardia, Sharon L. R.
Bomotti, Samantha M.
Turner, Stephen T.
Zagel, Alicia L.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-12
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Chronic kidney disease (CKD) is an increasing concern in the United States due to its rapidly rising prevalence, particularly among African Americans.
Epigenetic DNA methylation markers are becoming important biomarkers of chronic diseases such as CKD.
To better understand how these methylation markers play a role in kidney function, we measured 26,428 DNA methylation sites in 972 African Americans from the Genetic Epidemiology Network of Arteriopathy (GENOA) study.
We then evaluated (1) whether epigenetic markers are associated with estimated glomerular filtration rate (eGFR), (2) whether the significantly associated markers are also associated with traditional risk factors and/or novel biomarkers for eGFR, and (3) how much additional variation in eGFR is explained by epigenetic markers beyond established risk factors and biomarkers.
The majority of methylation markers most significantly associated with eGFR (24 out of the top 30) appeared to function, at least in part, through pathways related to aging, inflammation, or cholesterol.
However, six epigenetic markers were still able to significantly predict eGFR after adjustment for other risk factors.
This work shows that epigenetic markers may offer valuable new insight into the complex pathophysiology of CKD in African Americans.
American Psychological Association (APA)
Bomotti, Samantha M.& Smith, Jennifer A.& Zagel, Alicia L.& Taylor, Jacquelyn Y.& Turner, Stephen T.& Kardia, Sharon L. R.. 2013. Epigenetic Markers of Renal Function in African Americans. Nursing Research and Practice،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-490653
Modern Language Association (MLA)
Bomotti, Samantha M.…[et al.]. Epigenetic Markers of Renal Function in African Americans. Nursing Research and Practice No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-490653
American Medical Association (AMA)
Bomotti, Samantha M.& Smith, Jennifer A.& Zagel, Alicia L.& Taylor, Jacquelyn Y.& Turner, Stephen T.& Kardia, Sharon L. R.. Epigenetic Markers of Renal Function in African Americans. Nursing Research and Practice. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-490653
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-490653