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Factors Associated with the Decline of Kidney Function Differ among eGFR Strata in Subjects with Type 2 Diabetes Mellitus
Joint Authors
Tomita, Masuomi
Oikawa, Yoichi
Atsumi, Yoshihito
Shimada, Akira
Meguro, Shu
Itoh, Hiroshi
Katsuki, Takeshi
Kawai, Toshihide
Kabeya, Yusuke
Source
International Journal of Endocrinology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-18
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Introduction.
There is no report about risk factors for renal deterioration according to the clinical stage, divided by the estimated glomerular filtration rate (eGFR) in type 2 diabetes.
Materials and Methods.
We evaluated the factors correlated with the annual eGFR decline in 1303 subjects with type 2 diabetes whose eGFR was ≥30 mL/min/1.73 m2.
eGFR strata were defined by baseline eGFR value as follows: stratum 1: ≥90, stratum 2: ≥60, <90, and stratum 3: ≥30, <60.
Results.
The annual eGFR decline was 2.3±5.4 mL/min/1.73 m2 in overall subjects.
Multiple linear regression analysis demonstrated that age, male sex, systolic blood pressure, logarithmically transformed albumin excretion rate (AER), eGFR strata, and hemoglobin concentration were significantly correlated with the annual eGFR decline.
When stratified by eGFR, the factors that showed a significant correlation were different among eGFR strata.
AER was significantly correlated with annual eGFR decline in all eGFR strata.
Hemoglobin concentration showed a significant correlation only in the advanced eGFR stratum.
Conclusion.
The factors correlated with the annual eGFR decline were different among eGFR strata in type 2 diabetes mellitus, and hemoglobin concentration and AER were important factors for renal deterioration, especially in the advanced eGFR stratum.
American Psychological Association (APA)
Meguro, Shu& Tomita, Masuomi& Kabeya, Yusuke& Katsuki, Takeshi& Oikawa, Yoichi& Shimada, Akira…[et al.]. 2012. Factors Associated with the Decline of Kidney Function Differ among eGFR Strata in Subjects with Type 2 Diabetes Mellitus. International Journal of Endocrinology،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-490677
Modern Language Association (MLA)
Meguro, Shu…[et al.]. Factors Associated with the Decline of Kidney Function Differ among eGFR Strata in Subjects with Type 2 Diabetes Mellitus. International Journal of Endocrinology No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-490677
American Medical Association (AMA)
Meguro, Shu& Tomita, Masuomi& Kabeya, Yusuke& Katsuki, Takeshi& Oikawa, Yoichi& Shimada, Akira…[et al.]. Factors Associated with the Decline of Kidney Function Differ among eGFR Strata in Subjects with Type 2 Diabetes Mellitus. International Journal of Endocrinology. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-490677
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-490677