Plasma Vascular Endothelial Growth Factor Dysregulation in Defining Aggressiveness of Head and Neck Squamous Cell Carcinoma
Joint Authors
Boonkitticharoen, Vipa
Sritara, Chanika
Kulapaditharom, Boonchu
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-12-15
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
High circulating vascular endothelial growth factor (VEGF) levels tend to reflect tumor aggressiveness for being associated with tumor progression and prognosis.
Measurement of soluble VEGF receptor-1 (sVEGFR-1) may improve diagnostic power of VEGF assay.
Methods.
This study investigated regulation of plasma VEGF by sVEGFR-1 in 82 patients with head and neck squamous cell carcinoma compared with 32 healthy subjects to obtain information for assay characterization.
Results.
Normality or abnormality of VEGF/sVEGFR-1secretion patterns was rated into five diagnostic levels from definitely abnormal (likelihood ratios) (LRs = 4–∞) to definitely normal (LRs = 0–0.17).
Because of ineffective VEGF regulation, high grade tumor had a greater chance (62.5%) than low grade tumor (20%) in expressing a definitely abnormal pattern and a lower chance to express the normal pattern (P=0.007).
VEGF alone had much lower diagnostic power in differentiating between normal (LRs = 0.3–0.9) and abnormal secretion patterns (LRs = 2.2–2.4).
Conclusions.
VEGF dysregulation is suggestive of tumor aggressiveness for causing persistent plasma VEGF elevation.
sVEGFR-1 improves diagnostic power of VEGF assay particularly in identifying subset of low grade tumor with underlying aggressive disease and ruling out aggressiveness in subset of high grade tumor.
American Psychological Association (APA)
Kulapaditharom, Boonchu& Boonkitticharoen, Vipa& Sritara, Chanika. 2011. Plasma Vascular Endothelial Growth Factor Dysregulation in Defining Aggressiveness of Head and Neck Squamous Cell Carcinoma. Journal of Oncology،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-490681
Modern Language Association (MLA)
Kulapaditharom, Boonchu…[et al.]. Plasma Vascular Endothelial Growth Factor Dysregulation in Defining Aggressiveness of Head and Neck Squamous Cell Carcinoma. Journal of Oncology No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-490681
American Medical Association (AMA)
Kulapaditharom, Boonchu& Boonkitticharoen, Vipa& Sritara, Chanika. Plasma Vascular Endothelial Growth Factor Dysregulation in Defining Aggressiveness of Head and Neck Squamous Cell Carcinoma. Journal of Oncology. 2011. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-490681
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-490681