Multimodal Imaging of Alzheimer Pathophysiology in the Brain's Default Mode Network
Joint Authors
Shin, Jonghan
Barrio, Jorge R.
Small, Gary W.
Kepe, Vladimir
Phelps, Michael E.
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-04-19
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The spatial correlations between the brain's default mode network (DMN) and the brain regions known to develop pathophysiology in Alzheimer's disease (AD) have recently attracted much attention.
In this paper, we compare results of different functional and structural imaging modalities, including MRI and PET, and highlight different patterns of anomalies observed within the DMN.
Multitracer PET imaging in subjects with and without dementia has demonstrated that [C-11]PIB- and [F-18]FDDNP-binding patterns in patients with AD overlap within nodes of the brain's default network including the prefrontal, lateral parietal, lateral temporal, and posterior cingulate cortices, with the exception of the medial temporal cortex (especially, the hippocampus) where significant discrepancy between increased [F-18]FDDNP binding and negligible [C-11]PIB-binding was observed.
[F-18]FDDNP binding in the medial temporal cortex—a key constituent of the DMN—coincides with both the presence of amyloid and tau pathology, and also with cortical areas with maximal atrophy as demonstrated by T1-weighted MR imaging of AD patients.
American Psychological Association (APA)
Shin, Jonghan& Kepe, Vladimir& Small, Gary W.& Phelps, Michael E.& Barrio, Jorge R.. 2011. Multimodal Imaging of Alzheimer Pathophysiology in the Brain's Default Mode Network. International Journal of Alzheimer's Disease،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-490685
Modern Language Association (MLA)
Shin, Jonghan…[et al.]. Multimodal Imaging of Alzheimer Pathophysiology in the Brain's Default Mode Network. International Journal of Alzheimer's Disease No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-490685
American Medical Association (AMA)
Shin, Jonghan& Kepe, Vladimir& Small, Gary W.& Phelps, Michael E.& Barrio, Jorge R.. Multimodal Imaging of Alzheimer Pathophysiology in the Brain's Default Mode Network. International Journal of Alzheimer's Disease. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-490685
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-490685