![](/images/graphics-bg.png)
Song Bu Li Decoction, a Traditional Uyghur Medicine, Protects Cell Death by Regulation of Oxidative Stress and Differentiation in Cultured PC12 Cells
Joint Authors
Choi, Roy Chi-Yan
Chen, Jianping
Zhu, Kevin Yue
Miernisha, Abudureyimu
Lau, Kitty K. M.
Du, Crystal Y. Q.
Dong, Tina Ting-Xia
Tsim, Karl Wah-Keung
Aisa, Haji A.
Xu, Sherry Li
Maiwulanjiang, Maitinuer
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-28
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Song Bu Li decoction (SBL) is a traditional Uyghur medicinal herbal preparation, containing Nardostachyos Radix et Rhizoma.
Recently, SBL is being used to treat neurological disorders (insomnia and neurasthenia) and heart disorders (arrhythmia and palpitation).
Although this herbal extract has been used for many years, there is no scientific basis about its effectiveness.
Here, we aimed to evaluate the protective and differentiating activities of SBL in cultured PC12 cells.
The pretreatment of SBL protected the cell against tBHP-induced cell death in a dose-dependent manner.
In parallel, SBL suppressed intracellular reactive oxygen species (ROS) formation.
The transcriptional activity of antioxidant response element (ARE), as well as the key antioxidative stress proteins, was induced in dose-dependent manner by SBL in the cultures.
In cultured PC12 cells, the expression of neurofilament, a protein marker for neuronal differentiation, was markedly induced by applied herbal extract.
Moreover, the nerve growth factor- (NGF-) induced neurite outgrowth in cultured PC12 cells was significantly potentiated by the cotreatment of SBL.
In accord, the expression of neurofilament was increased in the treatment of SBL.
These results therefore suggested a possible role of SBL by its effect on neuron differentiation and protection against oxidative stress.
American Psychological Association (APA)
Maiwulanjiang, Maitinuer& Zhu, Kevin Yue& Chen, Jianping& Miernisha, Abudureyimu& Xu, Sherry Li& Du, Crystal Y. Q.…[et al.]. 2013. Song Bu Li Decoction, a Traditional Uyghur Medicine, Protects Cell Death by Regulation of Oxidative Stress and Differentiation in Cultured PC12 Cells. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-490688
Modern Language Association (MLA)
Maiwulanjiang, Maitinuer…[et al.]. Song Bu Li Decoction, a Traditional Uyghur Medicine, Protects Cell Death by Regulation of Oxidative Stress and Differentiation in Cultured PC12 Cells. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-490688
American Medical Association (AMA)
Maiwulanjiang, Maitinuer& Zhu, Kevin Yue& Chen, Jianping& Miernisha, Abudureyimu& Xu, Sherry Li& Du, Crystal Y. Q.…[et al.]. Song Bu Li Decoction, a Traditional Uyghur Medicine, Protects Cell Death by Regulation of Oxidative Stress and Differentiation in Cultured PC12 Cells. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-490688
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-490688