Ginkgo biloba Extract for Patients with Early Diabetic Nephropathy : A Systematic Review
Joint Authors
Liu, Zhuangzhu
Li, Xiaoyan
Liu, Xusheng
Li, Chuang
Lu, Zhaoyu
Mao, Wei
Zhang, Lei
Wu, Yifan
Guo, Rong
Jie, Xina
Wen, Zehuai
Guo, Xinfeng
Su, Guobin
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-02-24
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
Objectives.
To evaluate the effectiveness and safety of a Ginkgo biloba extract for patients with early diabetic nephropathy.
Methods.
Randomised controlled trials (RCTs) conducted on adults with early diabetic nephropathy which used Gingko biloba extract were included.
The major databases were searched, and manufacturers of Gingko biloba products were contacted for information on any published or unpublished studies.
Two authors independently extracted the data from the included studies.
Data analysis was conducted using Review Manager 5.0 software.
Results.
Sixteen RCTs were included.
Ginkgo biloba extract decreased the urinary albumin excretion rate (UAER), fasting blood glucose (FBG), serum creatinine (SCR), and blood urea nitrogen (BUN).
The extract also improved hemorheology.
The methodological quality in the included studies was low.
The explicit generation of the allocation sequence was described in only 6 trials.
None of the included trials were confirmed to use blinding.
Three studies had observed adverse events.
One study using angiotensin-converting enzyme inhibitor (ACEi) reported mild cough in both groups.
No serious adverse effects were reported.
Conclusions.
Gingko biloba extract is a valuable drug which has prospect in treating early diabetic nephropathy, especially with high UAER baseline level.
The safety for early diabetic nephropathy is uncertain.
Long-term, double-blinded RCTs with large sample sizes are still needed to provide stronger evidence.
American Psychological Association (APA)
Zhang, Lei& Mao, Wei& Guo, Xinfeng& Wu, Yifan& Li, Chuang& Lu, Zhaoyu…[et al.]. 2013. Ginkgo biloba Extract for Patients with Early Diabetic Nephropathy : A Systematic Review. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-17.
https://search.emarefa.net/detail/BIM-490699
Modern Language Association (MLA)
Zhang, Lei…[et al.]. Ginkgo biloba Extract for Patients with Early Diabetic Nephropathy : A Systematic Review. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-17.
https://search.emarefa.net/detail/BIM-490699
American Medical Association (AMA)
Zhang, Lei& Mao, Wei& Guo, Xinfeng& Wu, Yifan& Li, Chuang& Lu, Zhaoyu…[et al.]. Ginkgo biloba Extract for Patients with Early Diabetic Nephropathy : A Systematic Review. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-17.
https://search.emarefa.net/detail/BIM-490699
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-490699