Implementation Study of Patient-Ready Syringes Containing 25 mgmL Methotrexate Solution for Use in Treating Ectopic Pregnancy
Joint Authors
Viaud-Massuard, M. C.
Arlicot, C.
Antier, Daniel
Elfakir, C.
Respaud, Renaud
Gaudy, A. S.
Tournamille, J. F.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-12
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Background.
Ectopic pregnancy (EP) is a significant cause of morbidity and mortality during the first trimester of pregnancy.
Small unruptured tubal pregnancies can be treated medically with a single dose of methotrexate (MTX).
Objective.
The aim of this study was to evaluate the stability of a 25 mg/mL solution of MTX to devise a secure delivery circuit for the preparation and use of this medication in the management of EP.
Method.
MTX solutions were packaged in polypropylene syringes, stored over an 84-day period, and protected from light either at +2 to +8°C or at 23°C.
We assessed the physical and chemical stability of the solutions at various time points over the storage period.
A pharmaceutical delivery circuit was implemented that involved the batch preparation of MTX syringes.
Results.
We show that 25 mg/mL MTX solutions remain stable over an 84-day period under the storage conditions tested.
Standard doses were prepared, ranging from 50 mg to 100 mg.
The results of this study suggest that MTX syringes can be prepared in advance by the pharmacy, ready to be dispensed at any time that a diagnosis of EP is made.
Conclusion.
The high stability of a 25 mg/mL MTX solution in polypropylene syringes makes it possible to implement a flexible and cost-effective delivery circuit for ready-to-use preparations of this drug, providing 24-hour access and preventing treatment delays.
American Psychological Association (APA)
Respaud, Renaud& Gaudy, A. S.& Arlicot, C.& Tournamille, J. F.& Viaud-Massuard, M. C.& Elfakir, C.…[et al.]. 2014. Implementation Study of Patient-Ready Syringes Containing 25 mgmL Methotrexate Solution for Use in Treating Ectopic Pregnancy. BioMed Research International،Vol. 2014, no. 2014, pp.1-4.
https://search.emarefa.net/detail/BIM-490720
Modern Language Association (MLA)
Respaud, Renaud…[et al.]. Implementation Study of Patient-Ready Syringes Containing 25 mgmL Methotrexate Solution for Use in Treating Ectopic Pregnancy. BioMed Research International No. 2014 (2014), pp.1-4.
https://search.emarefa.net/detail/BIM-490720
American Medical Association (AMA)
Respaud, Renaud& Gaudy, A. S.& Arlicot, C.& Tournamille, J. F.& Viaud-Massuard, M. C.& Elfakir, C.…[et al.]. Implementation Study of Patient-Ready Syringes Containing 25 mgmL Methotrexate Solution for Use in Treating Ectopic Pregnancy. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-4.
https://search.emarefa.net/detail/BIM-490720
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-490720