Formulation Optimization of Erythromycin Solid Lipid Nanocarrier Using Response Surface Methodology
Joint Authors
Kumar, Tekeshwar
Sahu, Anil Kumar
Jain, Vishal
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-18
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
In present work response surface methodology (RSM) using the miscellaneous design model was used to optimize formulations of erythromycin solid lipid nanocarriers (ERY-SLN).
Two-factor three level factorial design was considered for optimization.
There were three parameters, drug entrapment efficiency (EE), drug loading (DL) percentage, and mean particle size of ERY-SLN, considered for investigating the optimal formulation with respect to two independent variables, including lipid concentration (X1) and surfactant : cosurfactant ratio (X2).
The result showed that the optimal ERY-SLN was composed of lipid concentration (X1) 15 mg/mL and surfactant : cosurfactant ratio (X2) 1 : 1 with %EE of 88.40 ± 2.09%, DL of 29.46 ± 0.69%, mean particle size of 153.21 ± 2.31 nm, polydispersity index (PDI) of 0.026 ± 0.008, and zeta potential value of −15.18 ± (−5.53) mV.
DSC and TEM study showed that there was no chemical interaction between ERY and lipid (GMS) and the ERY-SLN particles are nonspherical, respectively.
The drug release experiments exhibited a sustained release over during 24 h, up to 66.26 ± 2.83%.
Accelerated stability studies showed that there was no significant change occurring in the responses after storage condition for a total period of 3 months.
American Psychological Association (APA)
Sahu, Anil Kumar& Kumar, Tekeshwar& Jain, Vishal. 2014. Formulation Optimization of Erythromycin Solid Lipid Nanocarrier Using Response Surface Methodology. BioMed Research International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-490728
Modern Language Association (MLA)
Sahu, Anil Kumar…[et al.]. Formulation Optimization of Erythromycin Solid Lipid Nanocarrier Using Response Surface Methodology. BioMed Research International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-490728
American Medical Association (AMA)
Sahu, Anil Kumar& Kumar, Tekeshwar& Jain, Vishal. Formulation Optimization of Erythromycin Solid Lipid Nanocarrier Using Response Surface Methodology. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-490728
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-490728